妪松康防治绝经后骨质疏松症的实验研究

目的 :通过动物实验研究 ,客观地评价妪松康的防治效果 ,探讨其作用机理。方法 :采用去卵巢大鼠作为绝经后骨质疏松症的动物模型。 5 0只 3月龄雌性SD大鼠 ,随机分取 10只为假手术对照组 (SO组 ) ,其余大鼠摘取双侧卵巢并随机分为 4组 :模型组 (OVX组 ,n =8只 )、妪松康高剂组 (YH组 ,n =10只 )、妪松康低剂组 (YL组 ,n =10只 )、阳性对照仙灵骨葆组 (XL组 ,=10只 )。药物喂养 13周后处死。结果 :与OVX组比较 ,三治疗组血清E2 、P明显升高(P <0 .0 5 ) ,YH组、XL组股骨BMD升高 (P <0 .0 5 ) ,同时 ,YH组大鼠CT亦明显升高 (P <0 .0 5 ) ,子宫重增加 (P <0 .0 5 )、体重降低 (P <0 .0 5 )并均接近SO组 ,其结果优于XL组和YL组。结论 :妪松康能调节大鼠体内的激素水平 ,对骨骼有雌激素样的保护作用 ,对绝经后骨质疏松症有一定的防治作用

The Experimental Study of Yu-Song-Kang in Prevention and Cure Menopause Osteoporosis

Objective:To objectively appraise the effect and mechanism of Yu-Song-Kang through animal experiment. Methods:The animal model was made by cutting rat's ovary.Using 50 rats whose ages were 3 months.They were randomly divided 5 groups of SO group(n=10)?OVX group(n=8)?YH group(n=10)?YL group(n=10) and XL group(n=10).The rats were executed after feeding 13 weeks with medicines.Results: E2 and P were obviously raised in three treetment group than OVX group (P<0.05);Thighbone BMD was raised in YH and XL groups(P<0.05);The YH group's CT was raised(P<0.05)and uterus was weighter and body weight was lighter.The YH group was better than XL group and YL group.Conclusion:Yu-Song-Kang can adjust hormone level of rat and have protection action for bone and have prevention and cure action for menopause osteoporosis.