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Evolutionary Action Score of TP53 Enhances the Prognostic Prediction for Stage I Lung Adenocarcinoma
Authors:Yue Zhao  Han Han  Zhendong Gao  Hong Hu  Jiaqing Xiang  Yihua Sun  Haiquan Chen
Affiliation:2. Institute of Thoracic Oncology, Fudan University, Shanghai, China;3. State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China;4. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China;2. Department of Ophthalmology, The Northwestern University, Feinberg School of Medicine, Chicago. Chicago. IL. USA;2. Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany;3. Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania;4. Division of Thoracic Surgery, Department of Surgery, University of Maryland Medical Center, Baltimore, Maryland
Abstract:
Study overview. 83 patients with stage I lung adenocarcinoma were included in this study. Whole-exome sequencing was performed on surgical samples of these patients. Patients were further divided into 4 groups according to their TP53 mutational status. Tumor mutational burden, recurrence-free survival and overall survival were compared among different groups.
Image, graphical abstract
Keywords:
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