Serum protein fractions in C57BL mice during growth and senescence |
| |
| Affiliation: | 1. Center for the Study of Animal Science, ICETA, University of Porto, Rua de D. Manuel II, Apt 55142, 4051-401 Porto, Portugal;2. Department of Infectious Diseases, R&D Unit, INSA-National Health Institute Dr. Ricardo Jorge, Rua de Alexandre Herculano 321, 4000-055 Porto, Portugal;3. Clínica da Sagrada Esperança, Avenida Mortala Mohamed-Ilha de Luanda, Luanda, Angola;4. Experimental Pathology and Therapeutics Group, Research Center of Instituto Português de Oncologia, Rua Dr António B Almeida 4200-072 Porto, Portugal;5. Department of Microbiology, Immunology & Tropical Medicine, and Research Center for Neglected Diseases of Poverty, School of Medicine & Health Sciences, George Washington University, Washington, DC 20037 USA;6. CIQ-UP, Chemistry and Biochemistry Department, Faculty of Sciences, University of Porto, Rua do Campo Alegre 687, 4169-007 Porto, Portugal;1. Evolution & Ecology Research Centre, School of Biological, Earth and Environmental Sciences (BEES), the University of New South Wales, High Street, Kensington, NSW 2052, Australia;2. Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand |
| |
| Abstract: | Serum protein fractions havve been studied uantitatively, using a micromethod for starch gel electrophoresis combined with densitometric scans of the gel strips. Observations were made on C57BL male and female mice during the first 2 weeks of life, as well as on young adult and on senile animals. The main findings include: - 1.(i) a specific embryonic a1 globulin, the origin of which is unexplained and which disappears within the first 2 weeks of life;
- 2.(ii) a low βB globulin value in neonatal mice which increases during the first 2 weeks and which may tentatively be ascribed to the influence of maternal oestrogens during intrauterine life (cf. iii);
- 3.(iii) some differences between male and female sera, which occur as the animals attain sexual maturity, were experimentally shown to be caused by sex hormones. Most striking of these sex differences is the decreased βB globulin level caused by oestrogens;
- 4.(iv) in senile mice, few changes in serum protein fractions were found, except a marked elevation in the βB globulin fraction in females. This change perhaps is ascribable to decreased oestrogen production in old female mice. It was found experimentally that high oestrone doses may decrease this fraction to the young adult level.
|
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
