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| 局灶性脑缺血大鼠血管内皮生长因子的表达及意义 | |
| 引用本文： | 张爱梅,李宪章,杜留春,王纪佐.局灶性脑缺血大鼠血管内皮生长因子的表达及意义[J].中国临床神经科学,2002,10(4):365-367. |
| 作者姓名： | 张爱梅 李宪章 杜留春 王纪佐 |
| 作者单位： | 1. 山东省济宁医学院附属医院神经内科,272029 2. 山东省济宁市精神病院 3. 天津医科大学第二附属医院神经内科 |
| 摘 要： | 目的 :研究大鼠局灶性脑缺血后血管内皮细胞生长因子 (VEGF)表达的动态变化。方法 :采用尼龙线栓法制作大鼠局灶性永久性大脑中动脉闭塞模型 ,用免疫组织化学方法观察大鼠缺血后 3、6、12h和 1、2、3、7d时 ,VEGF表达的情况。结果 :大鼠缺血后 3h ,缺血侧脑组织开始出现VEGF表达 ,2 4h明显增多 ,2d达高峰 ,7d时仍有少量表达。各时间占VEGF的表达主要集中在梗死灶周围。结论 :VEGF可能参与缺血性脑损伤的病理发展及修复过程 |
| 关 键 词： | 脑缺血 血管内皮细胞生长因子 免疫组化 |
| 文章编号： | 1008-0678(2002)04-0365-03 |
| 修稿时间： | 2002年5月8日 |
Expression of Vascular Endothelial Growth Factor after Focal Ischemic Infarcts of Rats |
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| ZHANG Ai-Mei,LI Xian-Zhang,DU Liu-Chun,et al.Expression of Vascular Endothelial Growth Factor after Focal Ischemic Infarcts of Rats[J].Chinese Journal of Clinical Neurosciences,2002,10(4):365-367. | |
| Authors: | ZHANG Ai-Mei LI Xian-Zhang DU Liu-Chun |
| Institution: | ZHANG Ai-Mei,LI Xian-Zhang,DU Liu-Chun,et al Department of Neurology,Hospital Affiliated,Jining Medical College Shandong Province,272029,China |
| Abstract: | Aim:To investigate the expression of vascular endothelial growth factor (VEGF) in focal ischemic infarcts of rats.Methods:We made focal permanent cerebral ischemic infarcts model by occluding the middle cerebral artery with nylon line in rats. The changes of VEGF expression in brain tissue were investigated by immunohistochemistry.Results:It was found fhat VEGF expression started at 3h, and subsequently increased, reached peak value at the second day, failed away until 7d. VEGF expression was mainly detected in the periphery of the infarcts at every timepoint. Conclusion:VEGF may take part in the pathological and recovery process of ischemic stroke. |
| Keywords: | cerebral ischemia vascular endothelial growth factor immunohistochemistry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |