| L-精氨酸对高脂血症家兔血浆脂蛋白、一氧化氮和脂过氧化物的影响 |
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| 引用本文： | 杨永宗,陈颜芳,刘易林,林曙光,焦鸿丽,王周亮,丁翠芬,万腊香,杨和平.L-精氨酸对高脂血症家兔血浆脂蛋白、一氧化氮和脂过氧化物的影响[J].中国动脉硬化杂志,1995,3(3):206-211. |
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| 作者姓名： | 杨永宗 陈颜芳 刘易林 林曙光 焦鸿丽 王周亮 丁翠芬 万腊香 杨和平 |
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| 作者单位： | 衡阳医学院分子生物学研究中心，衡阳医学院第二附属医院心血管内科，广东省心血管病研究所，广州军区南岳制药厂 |
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| 摘 要： | 用雄性新西兰白兔观察了Ｌ－精氨酸对高脂血症时血浆脂蛋白、血清一氧化氨、脂过氧化物和超氧化物歧化酶的影响。结果发现２％Ｌ－精氨酸与２％胆固醇同时喂养９０天，或喂养９０天以后４％Ｌ－精氨酸治疗９０天，均能有效地抑制高胆固醇所致的血清脂过氧化物的升高，提高高脂血症家兔血清超氧化物歧化酶活性，促进血管内皮细胞一氧化氮的释放。结果提示，Ｌ－精氨酸／一氧化氮可能有抗高脂血症家兔低密度脂蛋白氧化修饰的作用。
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| 关 键 词： | L－精氨酸 高脂血症 家兔 脂过氧化物 一氧化氮 脂蛋白 |
Effect of L-arginine on Lipoprotein, Nitric Oxide and Lipid Peroxide in Hypercholesterolaemic Rabbits |
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| YANG Yong-Zong; CHEN Yan-Fang; LIU Yi-Lin; LIN Xu-Guang; JIAO Hong-Li; WANG Zhou-Lian; DIN Cui-Fen; WAN La-Xian; YANG He-Ping.Effect of L-arginine on Lipoprotein, Nitric Oxide and Lipid Peroxide in Hypercholesterolaemic Rabbits[J].Chinese Journal of Arteriosclerosis,1995,3(3):206-211. |
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| Authors: | YANG Yong-Zong; CHEN Yan-Fang; LIU Yi-Lin; LIN Xu-Guang; JIAO Hong-Li; WANG Zhou-Lian; DIN Cui-Fen; WAN La-Xian; YANG He-Ping |
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| Institution: | Molecular Biology Center, The Second Affiliated Hospital, Hengyang Medical College, Hengyang 421001; Guangdong Institute of Cardiovascular Disease, Guangzhou 510080; China |
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| Abstract: | We reported the effect of L-arginine on lipoprotein, nitric oxide(NO), lipid peroxide (LPO) and superoxide dismutase (SOD) in hypercholesterolaemic rabbit. The results showed that 2% L-arginine fed in company with 2% cholesterol for 90 days and 4%L-argine orally administrated for 90 days after 2%L-arginine and 2% cholesterol could significantly protect the activity NO and SOD, decrease the LPO content. L-Arg/NO may reduce the oxidative modification of LDL of hypercholesterolaemic rabbit. |
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| Keywords: | Hypercholesterolemia rabbit Lipid peroxidation Nitric oxide L-arginine Lipoprotein |
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