用于治疗糖尿病视网膜病变的抗血管新生药物

糖尿病视网膜病变是糖尿病的主要并发症,也是中老年人失明的重要原因之一。血管新生被普遍认为是糖尿病视网膜病变的治疗靶点。综述可用于治疗糖尿病视网膜病变的抗血管新生药物,包括抗血管内皮细胞生长因子药物、皮质类固醇激素、蛋白激酶C-β抑制剂和色素上皮衍生因子等的研究进展,为该类药物的深入开发和临床应用提供思路。

Anti-angiogenic Drugs for the Treatment of Diabetic Retinopathy

Diabetic retinopathy （DR） is the main complication of diabetes, and has become one of the significant causes of blindness among the middle-aged and old people. Angiogenesis has been widely considered as the therapeutic target in DR. The anti-angiogenie drugs for the treatment of DR, including anti-vascular endothelial cell growth factor （VEGF） drugs, corticosteroid hormones, protein kinase C-β （PKC-β） inhibitors and pigment epithelium derived factor （PEDF） were introduced in this paper, so as to provide the ideas for the further development and the clinical use of these drugs.