| 自身抗体检测对自身免疫性肝病的临床意义 |
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| 引用本文： | 加米拉·热扎克,李魏,张朝霞.自身抗体检测对自身免疫性肝病的临床意义[J].新疆医学,2011,41(6):1-4. |
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| 作者姓名： | 加米拉·热扎克 李魏 张朝霞 |
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| 作者单位： | 乌鲁木齐,新疆医科大学第一附属医院医学检验中心,新疆,830054 |
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| 摘 要： | 目的：探讨自身抗体检测对自身免疫性肝病诊断及鉴别的意义。方法：将696例受试对象分为3组：（1）AILD组：其中AIH患者41例，PBC患者142例；（2）病毒性肝炎组：乙型肝炎患者184例，乙型肝炎合并肝硬化患者81例，丙型肝炎患者160例，丙型肝炎合并肝硬化患者32例；（3）正常对照组56例。用间接免疫荧光法检测血清中ANA、AMA、ASMA和ANCA；用免疫印迹法检测AMA—M2型、SLA/LP、LKM-1和LC-1。结果：自身免疫性肝病组中ANA总阳性率为88．5％，高于其他各组（P〈0．01）；AIH组ASMA阳性率为17．1％，高于其他各组（P〈0．05）；PBC组AMA及AMA—M2亚型阳性率分别为84．5％和82．4％，明显高于其他各组（P〈0．05）；病毒性肝炎组中丙肝肝硬化患者ANA阳性率较高，为40．6％。结论：ANA，AMA及其亚型、ASMA等自身抗体检测是诊断自身免疫性肝病的重要指标，对各种类型的慢性肝病常规进行自身抗体检测有助于发现和鉴别AILD。
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| 关 键 词： | 自身免疫性肝病 自身抗体 核型 滴度 |
Clinical Significance of Autoantibodies for Checking Autoimmune Liver Disease |
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| Jiamila REZhAKE,LI Wei,ZHANG Zhaoxia.Clinical Significance of Autoantibodies for Checking Autoimmune Liver Disease[J].Xinjiang Medical Journal,2011,41(6):1-4. |
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| Authors: | Jiamila REZhAKE LI Wei ZHANG Zhaoxia |
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| Institution: | Jiamila REZhAKE,LI Wei,ZHANG Zhaoxia(Department of Laboratory Medicine,The First Affiliated Hospital of Xinjiang Medical University,Urumqi,830054,China) |
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| Abstract: | Objective To discuss the significance of autoantibodies for diagnosis and identification of autoimmune liver disease.Methods 696 subjects were divided into 3 groups as following:(1) AILD group including 41 patients with AIH and 142 patients with PBC.(2)Viral hepatitis group:184 patients with chronic hepatitis B,81 patients with chronic hepatitis B and cirrhosis,160 patients with chronic hepatitis C,32 patients with chronic hepatitis C and cirrhosis.(3)Control group including 56 health volunteers.ANA,ANCA,AS... |
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| Keywords: | autoimmune liver disease autoantibodies nuclear type titer |
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