二至丸考源及药理作用研究进展

对二至丸的来源和药理作用研究进行文献整理和分析。通过查阅古代医药文献及中国知网数据库,对二至丸方剂的来源和在药理作用研究方面取得的新进展,进行归纳整理并分类汇总。考证二至丸出自明代《扶寿精方》;现代药理作用表明,二至丸具有保肝降酶、抗肝纤维化、抗衰老、调节免疫机能、缩短血液凝血时间、改善血液流变性、抑制肿瘤、益智、抗炎、降血糖、抗疲劳等作用。近年来对其保肝作用研究较多,还需加强补肾滋阴等其他药理作用的研究,建立相关动物模型。建议对二至丸进行深入的作用机制研究,加强药代动力学及代谢组学研究,明确其发挥药效作用的物质基础,以期为二至丸临床应用和进一步开发提供依据。

Progress of Textual Research and Pharmacological Effects on Erzhi Pills

The origin of Erzhi pills and pharmacological effects were reviewed and analyzied. The ancient medical literatures and CNKI database were studied, the origin of Erzhi pills and pharmacological effects of the new progress were summarized and classified. It was indicated that it might derive from Fushou Jingfang of the Ming dynasty. Modern pharmacological studies have shown that it can be used in liver protection, liver fibrosis, anti-aging, immune function regulation, shortening the coagulation time, improving blood rheology, inhibiting rumor, increasing intelligence, anti-inflammatory, decreasing blood sugar, resisting fatigue. In recent years, study on the liver protection has more reports, other pharmacological effects, for instant the kidney Yin, need to be strengthen. Related animal model need to be established. It is suggest that further mechanism research, pharmacokinetic and metabolomics research should be proceeded. Material basis of therapeutic effects should be cleared in order to provide a basis of clinical application and further development.