大黄对急性氧化乐果中毒大鼠血浆胆碱酯酶和超氧化物歧化酶影响的实验研究

目的研究大黄对急性氧化乐果中毒急诊抢救治疗的辅助作用。方法用sD大鼠作为研究对象。将80只SD大鼠随机分为4组：轻度氧化乐果染毒组、重度氧化乐果染毒组、重度染毒后大黄治疗组和正常对照组。用不同剂量毒物对实验动物进行染毒，造成轻重不同程度的两组染毒动物模型（重度染毒2组、轻度染毒1组），然后将重度染毒组中的一组给予大黄治疗。结果大黄治疗组动物行为明显优于对照组，而且该组血浆中不同时间点的胆碱酯酶（ChE）和超氧化物歧化酶（SOD）明显高于其它两个中毒对照组（P〈0．01，P〈0．05）。结论大黄对急性氧化乐果中毒急诊抢救治疗有明显的辅助作用。

Experimental study on effects of Rhubarb treatment on the ChE and SOD in rats with acute omethoate poisoning

Objective To study the effect of Rhubarb as a supplemental emergency treatment for acute omethoate Poisoning (AOMP). Methods 80 male SD rats were randomly divided into 4 groups: slight intoxication group, severe intosieation group, therapeutial group of Rhubarb after severe intoxication and normal control group. The intoxication experimental model (one slight group, two severe groups) were made by intragastrically given at different dose of Omethoate. The severe group was received Rhubarb treatment. Results The rats action in Rhubarb treated group was significantly better than that in control group, and the level of cholinesterase (ChE) and superoxide dismutase (SOD) in serum st different time were significantly higher than those in other two intoxication groups. (P<0. 05 or P <0.01).Conclusions Rhubarb might be good for AOMP as a supple mental emergency therapy.