Miscarriage and use of multivitamins or folic acid |
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| Authors: | Andrew E Czeizel |
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| Institution: | 1. Department of Human Genetics, University Hospital Hamburg‐Eppendorf, Germany;2. Department of Psychiatry, University Hospital Hamburg‐Eppendorf, Germany;3. Albertinen‐Haus, Geriatric Centre, Hamburg, Germany;4. Scientific Institute for Research and Patient Care, S. Giovanni di Dio, Brescia, Italy;5. Division of Psychiatry Research, University of Zürich, Zürich, Switzerland;6. Department of Psychiatry, University of G?ttingen, G?ttingen, Germany;7. Department of Human Genetics, University of G?ttingen, G?ttingen, Germany |
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| Abstract: | In two recent studies from Germany, a strong association was found between the allelic variant T of the amino acid substitution encoding polymorphism 224 C/T (A38V) in exon 2 of the cathepsin D gene (CTSD) and late onset Alzheimer disease (AD). Other studies from Europe and the USA revealed ambiguous results. Therefore, we performed an independent association study on CTSD and AD in a sample of 324 Caucasian patients from Germany, Switzerland, and Italy with late onset AD, and 302 non‐demented controls. We could not confirm an association between CTSD genotype and AD, although there was a slight but not significant increase in frequency of the T allele and T carrier status in AD. Post hoc data analyses suggested that there might be a stronger effect of CTSD genotype on AD risk in males, and an interaction between CTSD and APOE genotypes in males but not females. © 2001 Wiley‐Liss, Inc. |
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| Keywords: | CTSD Cat D APOE interactions |
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