| 不同促渗剂对灯盏花素离体鼠皮透过行为影响 |
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| 引用本文： | 宋西卫,王颖,刘志东,解江纯,舒乐新. 不同促渗剂对灯盏花素离体鼠皮透过行为影响[J]. 辽宁中医杂志, 2011, 0(4): 750-752 |
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| 作者姓名： | 宋西卫 王颖 刘志东 解江纯 舒乐新 |
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| 作者单位： | 天津中医药大学现代中药发现与制剂技术教育部工程研究中心; |
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| 基金项目： | 国际科技合作计划项目(2007DFC31670); 国家科技支撑计划项目(2007BAI47B00,2007BAI47B01);国家科技重大专项(2009ZX09311-002) |
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| 摘 要： | 目的:研究新型促渗剂Transcutol P(Trans P)、Labrasol(Lab)以及传统促渗剂丙二醇(PG)对灯盏花素透皮行为的影响。方法:采用改良Franz扩散池,考察Trans P、Lab和PG在不同浓度下,对灯盏花素离体鼠皮透过行为的影响。结果:与空白组相比,5%Trans P、3%Trans P、3%PG、1%Trans P、与5%PG的表观渗透系数分别提高了2.54、2.01、1.64、1.51和1.47倍,有差异(P<0.05),几种促渗剂对灯盏花素透过的增渗作用依次为5%Trans P>3%Trans P>3%PG>1%Trans P>5%PG。结论:5%Trans P、3%Trans P、3%PG、1%Trans P、与5%PG的促渗效果比较明显,可进一步应用于灯盏花素透皮制剂中。
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| 关 键 词： | 促渗剂 灯盏花素 透皮 |
The effects of Different Penetration Enhancers on Breviscapinun Across the rat Skin in vitro |
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| SONG Xi-wei,WANG Ying,LIU Zhi-dong,XIE Jiang-chun,SHU Le-xin. The effects of Different Penetration Enhancers on Breviscapinun Across the rat Skin in vitro[J]. Liaoning Journal of Traditional Chinese Medicine, 2011, 0(4): 750-752 |
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| Authors: | SONG Xi-wei WANG Ying LIU Zhi-dong XIE Jiang-chun SHU Le-xin |
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| Affiliation: | SONG Xi-wei,WANG Ying,LIU Zhi-dong,XIE Jiang-chun,SHU Le-xin(Tianjin University of Traditional Chinese Medicine,Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique,Ministry of Education,Tianjin 300193,China) |
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| Abstract: | Objective：To study the effects of Lab,Trans P and PG on Breviscapinun across the rat skin.Methods：The Franz diffusion chamber was applied for evaluating the different concentrations of each penetration enhancer（PE） on the Breviscapinun permeability in vitro.Results：Compared with the control（P0.05）,5%Trans P、3%Trans P、3%PG、1%Trans P、and 5%PG increased the apparent permeability as much as 3.15、3.05、1.64、1.51 and 1.47times,（P0.05）.The penetration rate with the PE：5%Trans P3%Trans P3%PG1%Trans P5%PG.Conclusion：The enhance effect of 5%Trans P、3%Trans P、3%PG、1%Trans P、与5%PG was significant,and were likely to apply in the further research. |
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| Keywords: | penetration enhancer Breviscapinun transcutaneous |
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