特发性肺纤维化患者血清基质金属蛋白酶-9水平及其临床意义

目的探讨血清基质金属蛋白酶9水平对特发性肺纤维化患者早期诊断的价值。方法采用酶联免疫吸附法对32例特发性肺纤维化患者(早期组19例,非早期组13例)和24例健康人(健康对照组)血清基质金属蛋白酶9进行测定。结果早期组和非早期组血清基质金属蛋白酶9均高于健康对照组,差异有显著性意义(P<0.01);早期组血清基质金属蛋白酶9高于非早期组,两组间比较差异有显著性意义(P<0.01)。结论基质金属蛋白酶9在特发性肺纤维化发病机制中起着重要作用,血清基质金属蛋白酶9测定对特发性肺纤维化早期诊断具有一定价值。

Level of matrix metalloproteinase-9 in the serum of patients with idiopathic pulmonary fibrosis and its clinical significance

Objective To explore the value of serum matrix metalloproteinase-9(MMP-9) in the early diagnosis of idiopathic pulmonary fibrosis(IPF).Methods The serum level of MMP-9 in 32 cases with IPF(19 cases in early-stage group,13 cases in non early-stage group) and 24 healthy subjects (as control group) was measured by ELISA.Results The serum levels of MMP-9 in early-stage group and non early stage group were significantly higher than that of healthy control,with significant difference(P<0.01),the serum levels of MMP-9 in early-stage group were higher than that of no early stage,with significant difference(P<0.01).Conclusion MMP-9 plays an important role in the pathogenetic process of IPF and has certain value in the early diagnosis of IPF.