血尿酸与2型糖尿病颈动脉粥样硬化的相关性分析 |
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引用本文: | 冯田田,胡蕴,程程,毛晓明.血尿酸与2型糖尿病颈动脉粥样硬化的相关性分析[J].中华糖尿病杂志,2013(11):986-988. |
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作者姓名: | 冯田田 胡蕴 程程 毛晓明 |
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作者单位: | [1]连云港市妇幼保健院内科,222006 [2]南京医科大学附属南京医院(南京市第一医院)内分泌科,222006 |
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摘 要: | 目的 探讨T2DM患者SUA水平与颈动脉粥样硬化(CAS)的关系. 方法 纳入T2DM患者1411例,根据有无CAS将其分为颈动脉粥样硬化(A)组和非颈动脉粥样硬化(B)组,比较两组间的临床资料.并以颈动脉内膜-中层厚度(IMT)为因变量,以其他指标为自变量对合并后两组进行Spearman相关分析和Logistic回归分析. 结果 A组IMT、SUA、TG水平高于B组(P<0.05).Lo-gistic回归分析结果显示,SUA水平与IMT增厚相关(r=0.131,OR:1.021,95%CI:1.003~1.205).结论 T2DM患者SUA水平升高是CAS的独立危险因素.
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关 键 词: | 糖尿病 2型 动脉粥样硬化 高尿酸血症 颈动脉内膜-中层厚度 |
Correlation analysis between serum uric acid and carotid atherosclerosis in type 2 diabetes patients |
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Institution: | FENG Tian-tian,HU Yun CHENG Cheng( 1.Department of Internal Medicine, Lianyungang Maternity and Child Healthcare Hospital, Lianyungang 222006, China;) |
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Abstract: | Objective To investigate the relationship between the level of serum uric acid (SUA) and carotid atherosclerosis in type 2 diabetes patients.Methods 1411 patients with type 2 diabetes in hospital were collected.They were divided into two groups according to the carotid atherosclerosis,group A:with carotid atherosclerosis and grope B:without carotid atherosclerosis.The clinical characteristics were compared between the two groups.The intima-media thickness (IMT) as the dependent variable,other factors as independent variables,Spearman correlation analysis and logistic regression analysis were carried out.Results The IMT,SUA and TG levels in group A were all higher than in group B with significant differences (P<0.05).Logistic regression analysis showed that SUA level is a risk factor for IMT and carotid atherosclerosis.Conclusion Elevated SUA level is closely related to carotid atherosclerosis in type 2 diabetes. |
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Keywords: | Diabetes mellitus type 2 Carotid atherosclerosis Hyperuricemia Intima-media thickness |
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