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| 复方痤疮胶囊对痤疮丙酸杆菌的抑菌和抗炎作用实验研究 | |
| 引用本文： | 江丽,蔡果,龚春燕,申国庆. 复方痤疮胶囊对痤疮丙酸杆菌的抑菌和抗炎作用实验研究[J]. 中国药师, 2012, 15(8): 1098-1100 |
| 作者姓名： | 江丽 蔡果 龚春燕 申国庆 |
| 作者单位： | 中国医学科学院皮肤病医院药剂科,南京,210042 |
| 基金项目： | 2010年中央级公益性科研院所基本科研业务专项基金(编号:201006) |
| 摘 要： | 目的:观察复方痤疮胶囊的药理学作用,为临床用药和进一步的开发研究提供理论依据.方法:用平板法37℃厌氧培养痤疮丙酸杆菌72 h,定量测定复方痤疮胶囊最低抑菌浓度,并观察其对二甲苯致炎剂所致小鼠耳廓肿胀的影响.结果:复方痤疮胶囊对痤疮丙酸杆菌的最低抑菌浓度分别为200 mg·ml-1;复方痤疮胶囊2.4 g·kg-1,1.2 g·kg-1能有效地降低二甲苯致炎剂所致小鼠耳廓的肿胀(P<0.01).结论:复方痤疮胶囊有明显的抑菌、抗炎作用. |
| 关 键 词： | 复方痤疮胶囊 痤疮丙酸杆菌 抗炎 抑菌 |
| 收稿时间： | 2012-02-28 |
| 修稿时间： | 2012-04-12 |
Experimental Study on Antibacterial Effects against Propionibacterium Acnes and Anti inflammation of Fufang Cuochuang Capsules |
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| Jiang Li,Cai Guo,Gong Chunyan and Shen Guoqing. Experimental Study on Antibacterial Effects against Propionibacterium Acnes and Anti inflammation of Fufang Cuochuang Capsules[J]. China Pharmacist, 2012, 15(8): 1098-1100 | |
| Authors: | Jiang Li Cai Guo Gong Chunyan Shen Guoqing |
| Affiliation: | (Department of Pharmacy,Dermatological Hospital,Chinese Academy of Medical Sciences,Nanjing 210042,China) |
| Abstract: | Objective: To study the pharmacodynamics of Fufang Cuochuang capsules.Method: Propinibacterium acnes were cultured in an anaerobic condition at 37℃ for 72 hours by plating method.Result: The minimum inhibitory concentration of Fufang Cuochuang capsules for propinibacterium acnes was 200 mg·ml-1.Fufang Cuochuang capsules with the dose of 2.4 g·kg-1 and 1.2 g·kg-1 could significantly inhibit the swelling of mouse ears induced by xylene(P<0.01).Conclusion: Fufang Cuochuang capsules show obvious antibacterial and anti-inflammatory effects. |
| Keywords: | Fufang Cuochuang capsules Propinibacterium acnes Anti-inflammatory action Antibacterial effect |
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