唑来膦酸联合放疗治疗骨转移临床分析

目的 探讨唑来膦酸联合放疗治疗骨转移临床疗效、不良反应.方法 收集2009年3月至2010年2月安阳市肿瘤医院放疗科收治的148例恶性肿瘤骨转移病例进行回顾性分析.综合组:放射治疗+唑来膦酸注射液治疗80例;单放组:单纯行姑息性放射治疗68例.两组放疗均采用6 mV-X线大分割体外照射,3 GY/次,5次/周,总DT30 GY;综合组药物治疗为唑来膦酸注射液4 mg+0.9%NaCl 100 ml静脉滴注,15 min输完.结果 综合组和单放组的疼痛缓解率分别是 92.5%,91.2%,比较差异无统计学意义(P>0.05);两组不良反应发生比较无明显差异;骨转移灶再钙化有效率分别是68.8%,41.2%比较差异有统计学意义(P<0.05);疼痛缓解期:综合组6～20个月,单放组3～12个月.结论 唑来膦酸联合放疗治疗骨转移疗效明显,骨质修复、疼痛缓解期及患者生活质量均优于单纯放射治疗,并未见明显不良反应,是目前恶性肿瘤骨转移的常规治疗手段.

Clinical analysis for bone metastasis by radiotherapy plus zoledronic acid

Objective To explore the clinical effect of radiotherapy plus zoledronic acid for bone metastasis. Methods 148 patients with bone metastasis were analysised. Radiotherapy and chemotherapy group ： 80 cases were radiotherapy plus zoledronic acid injection treatment. Zoledronic acid injection 4 mg ＋ 0. 9% NaCl 100 ml static drops, 15 minutes after losing. Radiotherapy group：68 cases were palliative radiotherapy alone. Two groups of radiation was using 6 MV-X-ray big segmentation. Results The rates of pain relief were 92. 5%, 91.2% respectively. There were no significant difference（P 〉 0. 05 ）. The rates of bone metastases to calcification were 68.8% ,41.2% respectively. There were significant difference （P 〈 0. 05 ）. Conclusion The efficacy were better for patients with bone metastases by Zoledronic acid combined radiotherapy. Bone repair, the pain relief period and the quality of life of the patients are better than radiotherapy alone.