慢性乙型肝炎重叠戊型肝炎病毒感染的临床研究

目的探讨慢性乙型肝炎患者重叠戊型肝炎病毒（HEV）感染的临床特点及病情转归。方法采用酶联免疫吸附（ELISA）法检测甲、乙、丙、戊型肝炎病毒及乙肝病毒E抗原系统，同时检测肝功能（ALT、TBIL、ALB）和凝血功能（PT），筛选出慢性乙型肝炎重叠HEV感染患者127例与单纯戊型肝炎患者82例进行对比分析。结果慢性HBV重叠HEV感染（简称重叠组）127例（60．76％），单纯戊型肝炎患者82例（39．24％）。重叠组总胆红素（TBIL）、凝血酶厨时间（PT）、重型肝炎的发生率、住院时间和死亡率均明显高于单纯戊型肝炎组（P〈0．05或P〈0．01）。结论与单纯HEV感染者相比，慢性乙型肝炎重叠HEV感染者的肝脏损害更严重，死亡率更高，且预后更差，

Clinical Study on Characteristics of Chronic Hepatitis B Patients Superinfected with Hepatitis E Virus

Objective To investigate the clinical and epidemiological characteristics of chronic hepatitis B patients superinfected with hepatitis E virus（ simply named as HBV/HEV superinfection）. Methods Hepatitis A, B, C, D, G virus and hepatitis B virus surface antigen and HEV IgM were detected respectively by enzyme linked immunosorbent assay（ELISA）, 127 HBV/HEV superinfection patients and 82 simple HEV infection patients were selected,hepatic function（ALT,TBIL,ALB） and coagulation function（ prothrombin time,PT） were observed and compared between the group of HBV/HEV superinfection and the group of simple HEV infection. Results 127 cases （60.76%） were superinfected with HBV/HEV, and other 82 cases （39.23%） were infected with simple HEV. Total bilirubin（TBIL）,Prothrombin time（PT）, the incidence ratios of severe hepatitis, hospitalization days and mortality in the HBV/HEV superinfection group were obviously higher than those in the simple HEV infection group （ P 〈 0.05 or P 〈 0.01 ）. Conclusions Chronic hepatitis B patients superinfected with hepatitis E virus severely, damaged their hepatic functions and increased their mortality,with poorer prognosis compared to that of the simple HEV infection group.