Ketoacidosis,Hypertriglyceridemia and Acute Pancreatitis Induced by Soft Drink Polydipsia in a Patient with Occult Central Diabetes Insipidus |
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| Authors: | Yasutaka Tsujimoto Tomoaki Nakamura Jun Onishi Naoto Ishimaru Naoko Iwata Haruki Fujisawa Atsushi Suzuki Yoshihisa Sugimura Kazuo Chihara |
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| Affiliation: | 1.Department of Diabetes and Endocrinology, Akashi Medical Center Hospital, Japan; 2.Department of General Internal Medicine, Akashi Medical Center Hospital, Japan; 3.Department of Endocrinology and Diabetes, Daido Hospital, Japan; 4.Department of Endocrinology, Diabetes and Metabolism, Fujita Health University, Japan |
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| Abstract: | ![]()
A 21-year-old Japanese man without known diabetes mellitus had abdominal pain. The diagnosis was ketoacidosis and hypertriglyceridemia-induced acute pancreatitis. He had polydipsia and polyuria and had habitually drunk several soft drinks every day for two years. After hospitalization, despite adequate liquid intake, dehydration remained with hypotonic polyuria. Further examinations revealed the coexistence of central diabetes insipidus (CDI), possibly caused by lymphocytic infundibulo-neurohypophysitis, based on anti-rabphilin-3A antibody positivity. Although CDI had been undiagnosed for two years, over-consumption of sugar-rich soft drinks to ease thirst caused ketoacidosis, hypertriglyceridemia, and acute pancreatitis. There are no previous reports of this three-part combination of symptoms caused by CDI. |
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| Keywords: | ketoacidosis soft drink ketosis acute pancreatitis central diabetes insipidus lymphocytic infundibulo-neurohypophysitis anti-rabphilin-3A antibody |
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