CXCR4和VEGF—C在胃癌中的表达及与临床病理因素的关系

目的通过检测趋化因子受体4（CXCR4）和血管内皮生长因子C（VEGF—C）在人胃癌组织中的表达，探讨其与胃癌临床病理因素的关系。方法应用免疫组织化学方法，检测CXCR4和VEGF—C在人胃癌组织中的表达，同时对其与胃癌临床病理因素的关系进行统计学分析。结果CXCR4在胃癌组织中的阳性表达率为62％，其中无淋巴结转移组表达率为25％，淋巴结转移组表达率为73．68％，差异非常显著（P〈0．01）；无腹膜转移组表达率为（52．5％），显著低于腹膜转移组（100％）。VEGF—C在胃癌组织中的阳性表达率为72％。而且，CXCR4阳性表达与VEGF—C阳性表达呈显著正相关（K=0．597，P〈0．01）。胃癌CXCR4和VEGF—C的表达水平与肿瘤的组织分化程度、肿瘤浸润深度、淋巴结转移及TNM分期密切相关（P〈0．05）。结论CXCR4和VEGF—C有望成为胃癌分子诊断和病期评估的标志之一。

Relationship Between Expression of CXCR4 and VEGF - C in Gastric Cancer and Several Clinicopathological Factors.

Objective To investigate the relationship between expression of CXCR4 and VEGF - C in gastric cancer and several clinicopathological factors. Methods The expressions of CXCR4 and VEGF - C in 50 samples of human gastric cancer were detected by immuohistochemistry. The relationship between CXCR4 and VEGF - C expressions and the clinieopathologieal factors was statistically analyzed. Results The total positive rate of CXCR4 expression in these samples was 62% , and it was higher in the cases with lymphnode metastasis than that without lymphnode metastasis（73.68% vs 25% , P 〈 0.01 ）. And it was higher in the cases with peritoneal metastasis than that without peritoneal metastasis（ 100% vs 52.5% ,P 〈 0.01 ）. Meanwhile ,the total positive rate of VEGF - C expression was 72%. The positive expression of CXCR4 was consistent with the positive expression of VEGF - C （ K = 0. 597, P 〈 0.01 ） , and the expression levels of CXCR4 and VEGF- C were closely correlated with histological cellular differentiation, invasion depth, lymph node metastasis and TNM stage（ P 〈 0.05 ）. Conclusion CXCR4 and VEGF - C expressions may provide an evidence for molecular diagnosis and stage evalu- ation of gastric cancer.