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Evaluation of required saline volume in dynamic contrast-enhanced computed tomography using saline flush technique
Authors:Isao Yamaguchi  Eiji Kidoya  Masayuki Suzuki  Hirohiko Kimura
Affiliation:1. Radiological Center, University of Fukui Hospital, 23-3, Matsuokashimoaizuki, eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan;2. Division of Health Sciences, Kanazawa University Graduate School of Medicine Science, 5-11-80 Kodatsuno, Kanazawa, Ishikawa 920-0942, Japan;3. Department of Radiology, Facility of Medical Sciences, University of Fukui, 23-3, Matsuokashimoaizuki, eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan;1. Department of Radiology, Charité School of Medicine and University Hospital, Charitéplatz 1, 10117 Berlin, Germany;2. Department of Radiation Oncology, Charité School of Medicine and University Hospital, Augustenburger Platz 1, 13353 Berlin, Germany;3. Department of Radiology, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany;1. Department of Surgery, Division of Cardiothoracic Surgery, University of Miami Miller School of Medicine, Miami, FL, USA;2. Division of Cardiology, Abington Memorial Hospital, Abington, PA, USA;3. Department of Radiology, Jackson Memorial Hospital, University of Miami Miller School of Medicine, 1611 N.W., 12th Avenue, Miami, FL, USA;4. Department of Radiology, Texas Children''s Hospital, Baylor College of Medicine, Houston, TX, USA;5. Department of Medicine, Division of Cardiology, Kurashiki Central Hospital, Okayama, Japan;1. Department of Radiology, Gifu University Hospital, 1-1 Yanagido, 501-1194 Gifu, Japan;2. Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA;1. Department of Radiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China;2. Department of Radiology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China;3. Department of Radiology, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, China;1. University of Twente, MIRA-Institute for Biomedical Technology and Technical Medicine, Drienerlolaan 5, 7522 NB, Enschede, The Netherlands;2. Jeroen Bosch Hospital, Henri Dunantstraat 1, 5223 GZ, ''s-Hertogenbosch, The Netherlands;3. Department of Radiology, Jeroen Bosch Hospital, Henri Dunantstraat 1, 5223 GZ, ''s-Hertogenbosch, The Netherlands;1. Dpt of Radiation Oncology, Complejo Hospitalario Universitario de Albacete (CHUA), Spain;2. Dpt of Radiology, Complejo Hospitalario Universitario de Albacete (CHUA), Spain;3. Dpt of Radiation Oncology, Hospital Son Espases, Palma de Mallorca, Spain;4. Radiation Oncology Department, ICMHO, Hospital Clinic, University of Barcelona, IDIBAPS, Spain;5. Unidad de Medicina Molecular, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, Albacete, Spain;6. Unidad asociada de Biomedicina, UCLM-CSIC, Albacete, Spain;7. Dpt of Radiation Oncology, Hospital Universitari Sant Joan, Reus, Spain
Abstract:
The present study was performed to find the required volume of physiological saline for flushing that will allow the most efficient use of contrast medium during the early phase of dynamic CT. We calculated contrast medium aortic arrival time (AT), time to peak aortic enhancement (TPAE) and the elapsed time to TPAE from AT (rise time) from the TECs of pharmacokinetic analysis and clinical study. The rise time determined in the clinical study was 6.2 s, which was shorter than that in the simulation study. In the present study, an appropriate volume for saline flush was estimated to be about 18 ml.
Keywords:
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