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Neuropsychological tests as discriminators between dementia of alzheimer type and frontotemporal dementia
Authors:Christina Elfgren  Arne Brun  Lars Gustafson  Aki Johanson  Lennart Minthon  Ulla Passant  Jarl Risberg
Abstract:The aim of this study was to examine whether cognitive test performance alone could distinguish patients with dementia of Alzheimer type (DAT) from those with frontotemporal dementia (FTD). Scores from three neuropsychological tests were used as discriminating variables in 28 cases with postmortem verified diagnoses. The selected tests measured verbal ability, visuospatial ability and verbal memory. Eighty-nine per cent of the sample was correctly classified by discriminant analysis. Evaluating the ability of the obtained discriminant function to differentiate between groups of DAT and FTD in a new, clinically diagnosed sample of 38 cases yielded an overall success rate of 84%. The results suggest that cognitive tests may be helpful for differential diagnosis in the context of a neuropsychiatric examination.
Keywords:Dementia of Alzheimer type  frontotemporal dementia  neuropsychological tests  discriminant analysis  postmortem examination  clinical diagnosis  regional cerebral blood flow
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