Anti-inflammatory activity of Lannea coromandelica bark extract in rats

Oral administration of an ethanolic extract of Lannea coromandelica (ELC) demonstrated a dose related antiinflammatory activity (AIA) in carrageenan and dextran induced oedema and adjuvant induced arthritis in rats. ELC reduced the pleural exudate volume and inhibited leucocyte migration in carrageenan-induced pleurisy in rats. It lacked analgesic, antipyretic or ulcerogenic effect and failed to exhibit any effect in cotton pellet granuloma. It did not prolong the gestation period, parturition time in pregnant rats or the onset time of diarrhoea in rats induced by castor oil. The ALD₅₀ is greater than 2 g/kg p.o. in mice.