三七通舒胶囊对急性脑梗死不同时间点血清VEGF和IL-6表达的影响

目的评价三七通舒胶囊有效成分三七三醇皂苷（PTS）对急性脑梗死（ACI）患者血清白介素-6（IL-6）和血管内皮生长因子（VEGF）表达的影响。方法纳入发病72？h内入院的急性脑梗死患者,分为PTS组和尼莫同组,以年龄、性别与纳入急性脑梗死患者匹配的健康正常人作为对照组。对脑梗死病人于发病后3、7、14和28天四个时间点采血,采用ELISA法测定血清IL-6和VEGF的含量。结果脑梗死病人的血清VEGF水平在四个时间点均持续升高,IL-6含量在病后第3天显著升高,以后下降。PTS组与尼莫同组和正常对照组比较,可使IL-6明显下降（P〈0.05）和使VEGF表达明显上升（P〈0.01）。结论 PTS在各时间点均显著增加脑梗死后血清VEGF的含量,且能使其维持在一个较高的水平,同时在早期降低血清IL-6水平,推测这可能是PTS治疗急性脑梗死的分子机制之一。

Effect of Sanqi Tongshu Capsule on the Serum Level of IL-6 and VEGF Expression of Different Periods of Acute Cerebra Infarction

Objective To research on the effect of protoparaxaxotrid saporlirs （PTS）, active component in Sanqi Tongshu Capsule, on the expressions of the serum level of IL-6 and VEGF of patients with the acute cerebral infarction at different time points. Method 86 patients were randomly divided into two groups： PTS group and Nimodipine group, healthy person as control group. ELISA was applied to measure the serum level of IL-6 and VEGF in during different phases （3 d, 7 d, 14 d and 28 d after the onset of cerebral infarction）. Results The expressions of VEGF rose signi cantly in the all of ACI patients. The expressions of IL-6 rose signi cantly on third day, then began to decrease. The serum level of IL-6 declined signi cantly （P0.05） and the serum level of VEGF rose in both of PTS group and Nimodipine group in contrast with control group （P0.01）. Conclusion PTS can promote the expressions of VEGF after the cerebral infarc-tion at different time points, and decrease the expressions of IL-6 in the early period of ACI, decreased,which may be one of the molecular mechanisms of this PTS in treating acute cerebral infarction.