鹿瓜多肽联合美洛昔康治疗老年类风湿性关节炎的疗效观察

目的 探讨鹿瓜多肽联合美洛昔康治疗老年类风湿性关节炎的疗效.方法 将患类风湿性关节炎的老年患者68例随机分成A组和B组,分别给予美洛昔康、鹿瓜多肽联合美洛昔康,治疗前后检测血沉、C-反应蛋白(CRP)、类风湿因子(RF)、肝功能、血常规及尿常规,并观察患者关节疼痛、肿胀、晨僵时间等症状改善情况.结果 治疗5周后,鹿瓜多肽联合美洛昔康和美洛昔康组的总有效率分别为82.35％和70.59％,两组患者的晨僵时间、双手平均握力、关节压痛数目、关节肿胀数目、关节压痛数、关节压痛指数等均明显好转,具有显著性差异(P＜0.05),其中鹿瓜多肽+美洛昔康组的晨僵时间、关节压痛数、关节压痛指数改变优于美洛昔康组(P＜0.05).结论 瓜多肽注射液联合美洛昔康治疗老年类风湿性关节炎具有良好的效果,而且毒副作用较小.

Efficacy Observation of Lugua Polypeptide Combined with Meloxicam in Treatment of Senile Rheumatoid Arthritis

Objective To investigate the clinical efficacy of Lugua polypeptide combined with meloxicam in treatment of senile rheuma- toid arthritis. Methods 68 elderly cases of rheumatoid arthritis were randomly divided into 2 groups （A and B） and treated with meloxicam and Lugua polypeptide combined with meloxicam, respectively. The erythrocyte sedimentation rate（ESR）, C- reaction protein （CRP）, rheumatoid factor（RF）, liver function, blood routine and urine routine were detected before and after treatment in the two groups. The improvement conditions of joint pain, swelling and morning stiffness were observed. Results After 5 weeks treatment, the ef-fective rates of the Lugua polypeptide combined with meloxicam group and the meloxicam group were 82.35% and 70. 59%, respec-tively; the morning stiffness time, average grip strength of two hands, joint tenderness number, joint swelling number rest pain, joint swelling index and joint tenderness index in the two groups were obviously improved with statistical differences（P〈 0.05）. Among them, the improvement of the morning stiffness time, joint tenderness number and joint tenderness index in the Lugua polypeptide com-bined with meloxicam group was superior to that in the meloxicam group（ P 〈 0. 05）. Conclusion Lugua Polypeptide Injection com-bined with meloxicam has good effect and less adverse reactions in treatment of senile rheumatoid arthritis.