| 高效液相色谱法测定非布司他片的含量 |
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| 引用本文： | 冷柏榕,严相平. 高效液相色谱法测定非布司他片的含量[J]. 中国药业, 2013, 0(6): 69-70 |
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| 作者姓名： | 冷柏榕 严相平 |
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| 作者单位： | 南京工业大学·江苏省药物研究所,江苏南京210009 |
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| 摘 要： | 目的建立测定非布司他片含量的高效液相色谱法。方法色谱柱为Kromasil-C18柱(250 mm×4.6 mm,5μm),流动相为甲醇-0.05%磷酸溶液(80∶20),流速为1.0 mL/min,检测波长为317 nm。结果非布司他质量浓度在32.4～48.6μg/mL范围内与峰面积线性关系良好(r=0.999 0),平均回收率为99.58%,RSD=1.13%。结论该方法简便快速,灵敏、准确,适用于测定非布司他片中非布司他的含量,可作为非布司他制剂的质量控制方法。
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| 关 键 词： | 高效液相色谱法 非布司他 含量测定 |
Content Determination of Febuxostat Tablets by HPLC |
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| Leng Borong,Yan Xiangping. Content Determination of Febuxostat Tablets by HPLC[J]. China Pharmaceuticals, 2013, 0(6): 69-70 |
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| Authors: | Leng Borong Yan Xiangping |
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| Affiliation: | Leng Borong, Yah Xiangping ( Jiangsu Provincial Research Institute of Material Medica , Nanjing University of Technology, Nanjing , Jiangsu , China 210009) |
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| Abstract: | Objective To establish an HPLC method for the determination of Febuxostat Tablets. Methods The method was pertormed on the Kromasil-C18 column（250 mm ×4.6mm,5μm） with methanol-0.05% phosphoric acid solution（80：20） as the mobile phase at a flow rate of 1.0 mL/min. The detection wavelength was at 317 nm. Results The linear range of febuxostat was 32.4 -48.6 μg/mL （r =0. 999 0）,the average recovery rate was 99.58%, RSD = 1.13%. Conclusion This method is rapid,sensitive and accurate,which is suitable for determining the febuxostat content in Febuxostat Tablets and can be used as the quality control method of febuxostat preparations |
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| Keywords: | HPLC febuxostat content determination |
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