新显色剂5-APAQ分光光度法直接测定药品中的残留钯

 目的：建立一种药品中有害杂质钯残留量的测量技术。方法：采用新试剂5-（对-胂酸基苯偶氮）-8-氨基喹啉（5-APAQ）与钯发生络合反应显色，用分光光度法进行测量。结果：在pH10～14的水溶液中，显色络合物的最大吸收波长为653nm，摩尔吸收系数为1．05×10⁵，吸光度与钯含量在0μg·ml^－1～1．2μg·ml^－1成线性关系。结论：实验证明，本方法特异性强、灵敏度高、操作简便快捷。

Spectrophotometric determination of trace toxicant impurity palladium in medicine with 5 (p arsonophenylazo) 8 aminoquinoline

OBJECTIVE: To establish a method for determination of palladium remaining in medicines. METHOD: A spectrophotometric method was developed using 5-(p-arsonophenylazo)-8-aminoquinoline as a new complex chromogenic agent to react with palladium forming a complex in the presence of cetyltrimethyl ammonium bromide. RESULTS: In water solution of pH 10～14, the maximum absorbance wavelength of the complex was at 653 nm and its molar absorptivity was 1.05×10⁵. The Beer's law was obeyed over the range 0 μg～1.2 μg Pd (Ⅱ) in 1 ml solution. CONCLUSION: This method was proved to be selective, sensitive, simple, and rapid.