| 非酶糖基化终末产物所致疾病的中药干预 |
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| 引用本文： | 韩莹,史道华. 非酶糖基化终末产物所致疾病的中药干预[J]. 中草药, 2005, 36(6): 938-941 |
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| 作者姓名： | 韩莹 史道华 |
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| 作者单位： | 南京军区福州总医院,药理科,福建,福州,350025 |
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| 摘 要： | 非酶糖基化终末产物(AGEs)是蛋白质、脂质和核酸等大分子的游离氨基与还原性单糖的醛基反应所生成的稳定的共价化合物,在体内的积累是导致糖尿病等多种疾病及其并发症的关键因素。AGEs可直接或间接地对机体产生致病作用。目前AGEs抑制剂特别是某些中药在治疗AGEs引起的疾病方面研究进展迅速,主要通过降低体内AGEs水平、减少AGEs交联、抗氧化、阻断与相关受体的结合等途径来干预AGEs的合成、代谢和受体后效应。简述AGEs的致病机制,并探讨中药对AGEs所致疾病的干预及其可能机制。
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| 关 键 词： | 非酶糖基化终末产物 糖尿病并发症 中药 |
| 文章编号： | 0253-2670(2005)06-0938-04 |
| 收稿时间： | 2004-09-29 |
Diseases induced by advanced glycation end products and their treatments with Chinese materia medica |
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| HAN Ying and SHI Dao-hua. Diseases induced by advanced glycation end products and their treatments with Chinese materia medica[J]. Chinese Traditional and Herbal Drugs, 2005, 36(6): 938-941 |
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| Authors: | HAN Ying and SHI Dao-hua |
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| Affiliation: | Department of Pharmacology, Fuzhou General Hospital of Nanjing Military Command, Fuzhou 350025, China;Department of Pharmacology, Fuzhou General Hospital of Nanjing Military Command, Fuzhou 350025, China |
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| Abstract: | |
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| Keywords: | advanced glycation end products (AGEs) diabetic complications Chinese materia medica |
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