吸烟对男性不育患者精子活力和动态参数的影响及相关性研究

目的 探讨吸烟对男性精液质量的影响并分析不育患者精子活力和动态参数的相关性.方法 应用伟力彩色精子质量分析系统对255例男性不育患者(吸烟组96例、非吸烟组84例和烟酒组75例)和112名正常生育男性的精子活力、直线运动速度(VSL)、曲线运动速度(VCL)、平均路径速度(VAP)、平均移动角度(MAD)、侧摆幅度(A...

The study of correlation and influence of cigarette smoking on the sperm motility and the kinesis parameters in infertile males

Objective To study the influence of cigarette smoking on the sperm quality and the correlation between the motility of sperm and the kinesis parameters in infertile males.Methods A total of 255 infertile males（96 smokers,84 non-smokers and 75 smokers with drinking）and 112 fertile controls were enrolled in the study and were determined by WEILI colour semen analysis system.The sperm kinesis parameters,including sperm motility,velocity of straight line（VSL）,velocity of curvilinear（VCL）,velocity of average path（VAP）,migratory degree（MAD）,amplitude of oscillation（ALH）,beat cross frequency（BCF）,straightness（STR）,linearity（LIN） and wobble（WOB）,were determined,and their correlations were also analyzed.Results Compared with the controls,there was a significant decrease in the sperm motility,VSL,VCL,VAP,ALH,LIN and STR（P0.05,P0.01）,and there was a marked increase in BCF in the infertile smokers,non-smokers and smokers with drinking（P0.05,P0.01）.The sperm motility was much lower in the infertile smokers than in the infertile non-smokers（P0.05,P0.01）.The sperm motility,VSL,VCL,VAP,MAD and ALH were significantly lower in the infertile smokers with drinking than in the infertile smokers（P0.05,P0.01）,while BCF increased obviously（P0.01）.The sperm motility,VSL,VCL and ALH in the small-quantity and short-time smoking group were also higher than those in the big-quantity and long-time smoking group（P0.05,P0.01）,and BCF increased in the small-quantity smoking group（P0.01）.Moreover,VAP and LIN in the long-time smoking group decreased significantly than in the short-time smoking group（P0.05,P0.01）.There were significant positive correlations between the sperm motility and VSL,VCL,VAP,LIN and STR（P0.05）.Furthermore,there was a significant negative correlation between the sperm motility and BCF（P0.001）.Conclusions Cigarette smoking is remarkably associated with abnormal sperm motility and sperm kinesis parameters.Smoking may be an independent risk factor for the infertility of males.The influence of smoking on the abnormal sperm motility and sperm kinesis parameters has a dose-effect and time-effect relationship.VSL,VCL,VAP,LIN,STR and BCF are valuable parameters to evaluate the sperm motility of smoking infertile males.