彩色多普勒超声评价乳腺癌新辅助化疗疗效的研究

目的:分析与新辅助化疗疗效相关的乳腺癌癌肿的声像图指标变化,与病理学检查结果进行比较,探讨彩色多普勒超声在乳腺癌新辅助化疗疗效评价上的应用价值。方法:利用彩色多普勒超声对接受新辅助化疗的43例乳腺癌患者的乳腺癌病灶变化进行观察,应用RECIST标准对乳腺癌新辅助化疗疗效进行评价,总结与新辅助化疗疗效相关的声像图指标。结果:本组43个病例通过临床触诊对新辅助化疗疗效进行评价,与病理学疗效评价符合率34.89%,敏感度59.09%;彩色多普勒超声检查评价乳腺癌病灶变化与病理学评价的符合率72.09%,敏感度86.36%,在病理判定有效组,新辅助化疗前后病灶内血流分级类型及RI值变化均具有显著性差异(P<0.05)。在病理判定无变化组,新辅助化疗前后病灶内血流分级类型及RI值变化均不具有显著性差异(P>0.05)。结论:彩色多普勒超声检查结合乳腺癌病灶的二维图像及血流信息,能对乳腺癌新辅助化疗后的疗效做出客观评价,具有一定的临床应用价值。

Study of Color Doppler Ultrasonography in evaluating effcet of neoadjuvant chemotherapy to breast carcinoma

Objective:To study the relation of sonographical characters with the effect of neoadjuvant chemotherapy for breast cancer.Methods:All 43 patients with breast carcinoma were given CEF(CTX+EPI+5-FU).All the lesions were undergone CDFI.Results:According to the clinical palpation,the accuracy,sensitivity for palpation in evaluating effect of neoadjuvant chemotherapy were 34.89%,59.09%.According to the length of breast carcinoma lesion,the accuracy,sensitivity for US in evaluating effect of neoadjuvant chemotherapy were 72.09%,86.36%.In partial remission group,there were significant differences in the blood mode and RI value of the breast tumors between before and after chemotherapy(P<0.05).In unchanged group,there was no difference in the blood mode and RI value of the breast tumors between before and after chemotherapy(P>0.05).Conclusion:It was useful to appraise the effect of neoadjuvant chemotherapy to breast carcinoma by Color Doppler Ultrasonography.