| 前房相关性免疫偏离研究进展 |
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| 引用本文： | 胡维琨,张虹. 前房相关性免疫偏离研究进展[J]. 眼科新进展, 2005, 25(2): 178-180 |
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| 作者姓名： | 胡维琨 张虹 |
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| 作者单位： | 430030,湖北省武汉市,华中科技大学同济医学院附属同济医院眼科 |
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| 摘 要： | 前房相关性免疫偏离(anterior chamber-associated immune deviation．ACAID)是一种机体主动的下调性免疫反应，它有以下几个特点：(1)抑制抗原特异性迟发型超敏反应；(2)抑制补体结合性抗体的分泌；(3)产生抗原特异性致敏的细胞毒T淋巴细胞；(4)产生抗原特异性非补体结合性抗体。其临床意义在于：(1)通过诱导ACAID提高角膜、视网膜等眼组织移植的成功率；(2)通过诱导ACAID防治葡萄膜视网膜炎。避免发生疱疹性角膜基质炎；(3)通过消除ACAID避免其不利影响。
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| 关 键 词： | 前房相关性免疫偏离 葡萄膜炎 角膜移植 |
| 文章编号： | 1003-5141(2005)02-0178-03 |
| 修稿时间： | 2003-07-21 |
Advances in the study of anterior chamber-associated immune deviation |
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| HU Wei-Kun,ZHANG Hong. Advances in the study of anterior chamber-associated immune deviation[J]. Recent Advances in Ophthalmology, 2005, 25(2): 178-180 |
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| Authors: | HU Wei-Kun ZHANG Hong |
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| Affiliation: | HU Wei-Kun,ZHANG HongFrom the Department of Ophthalmology,Tongji Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei Province,China |
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| Abstract: | The development of an initiative systemic tolerance was called anterior chamber-associated immune deviation (ACAID).There were several characterization that suppression of antigen-specific delayed hypersensitivity firstly,suppression of antibodies fixing complement secondly,production of antigen-specific cytotoxic T lymphocyte thirdly,and finally the production of antigen-specific antibodies that non-fixing complement.This phenomenon of ACAID had important clinical significance on eye vision.First,we can enhance successful rate of cornea and retina transplantaion by inducing ACAID;Second,we can also prevent and cure uveitis and retinitis and avoid Herpes interstitial keratitis by inducing ACAID;Finally,we can avoid its disadvantage by abolishing ACAID. |
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| Keywords: | anterior chamber-associated immune deviation uveitis cornea transplantation |
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