益脉降压充浸膏对老年高血压病患者血小板活化,纤溶？…

目的：观察益脉降压流浸膏对老年气虚血瘀证型Ⅱ期高血压患者活化血小板α－颗粒膜蛋白（ＧＭＰ－１４０）、组织型纤溶酶原激活剂（ｔ－ＰＡ）及其抑制剂（ＰＡＩ）、血管紧张素Ⅱ（ＡｎｇⅡ）的影响。方法：采用放射免疫不及比色分析法测定４２例老年握虚血瘀证Ⅱ期高血压病患者（治疗组）应用降压流浸膏治疗前后ＧＭＰ－１４０、ｔ－ＰＡ、ＰＡＩ及ＡｎｇⅡ水平，并与３０例应用卡托普利治疗的患者（对照组）及３０名老年健康人（

Effect of yimai jiangya extract on platelet activation and fibrinolytic activity and angiotensin II in aged patients with essential hypertension]

OBJECTIVE: To observe the effect of Yimai Jiangya extract (YMJYE) on platelet alpha-granule membrane protein (GMP-140), tissue-type plasminogen activator (t-PA) and its inhibitor (PAI), angiotensin II (AngII) in aged patients with essential hypertension (EH) of stage 2 caused by Qi deficiency and blood stasis. METHODS: Radioimmunoassay (RIA) and colorimetric analysis were used to examine the levels of GMP-140, t-PA, PAI and AngII before and after treatment with YMJYE in 42 aged patients (treated group), compared with that of 30 aged patients before and after treatment with captopril (control group) and 30 aged healthy subjects (healthy group). RESULTS: Before treatment, GMP-140, PAI and AngII were significantly higher (P < 0.01), and t-PA were obviously lower (P < 0.01) in the treated and the control group compared with those in the healthy group. After treatment, the improvement of GMP-140, t-PA, PAI and AngII in the treated group were obvious (P < 0.05, P < 0.01). The improvement of GMP-140, t-PA, PAI in the treated group was more significant than that of control group (P < 0.05, P < 0.01), while the improvement of AngII in the treated group was worse than that of the control group (P < 0.01). After treatment, there was insignificant changes about the levels of blood pressure between the treated group and the control group (P > 0.05). CONCLUSIONS: In the aged patients, GMP-140, PAI and AngII were increased, t-PA reduced. The effects of YMJYE in inhibiting platelet activation and improving fibrinolytic activity were better than that of captopril. These findings indicated that the mechanisms of inhibiting platelet activation and improving fibrinolytic activity and lowering blood pressure of YMJYE were correlated with decreasing the levels of AngII, but other mechanisms may also exist.