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| ER、CyclinD1蛋白在青春期乳房肥大症乳腺组织中的表达 | |
| 引用本文： | 任敏,汪英,滕利,王本忠.ER、CyclinD1蛋白在青春期乳房肥大症乳腺组织中的表达[J].内分泌外科杂志,2009,3(5):304-307. |
| 作者姓名： | 任敏 汪英 滕利 王本忠 |
| 作者单位： | 1. 安徽医科大学第一附属医院乳腺外科,合肥,230022 2. 安徽医科大学附属安徽省市医院二南病区 3. 中国医学科学院中国协和医科大学整形外科医院整形五科,北京,100144 |
| 摘 要： | 目的探讨ER、CyclinD1蛋白在青春期乳房肥大症乳腺组织中的表达及意义。方法应用Western-blot法检测15例青春期乳房肥大症（实验组）、15例正常乳腺（对照组B）及10例原发性小乳症（对照组A）乳腺组织中ER、CyclinD1蛋白的表达情况。结果ER、CyclinD1蛋白在实验组乳腺组织中的表达与对照组A乳腺组织中的表达比较差异有统计学意义（P〈0．01），ER、CyclinD1蛋白在实验组乳腺组织中的表达与对照组B组织中的表达比较差异有统计学意义（P〈0．01），ER、CyclinD1蛋白在对照组B组织中的表达与对照组A乳腺组织中的表达比较差异无统计学意义（P〉0．05）。结论ER、CyclinD1蛋白在实验组乳腺组织中的表达明显高于对照组B和对照组A乳腺组织中的表达乳房肥大症的发生可能与乳腺组织中ER、CyclinD1蛋白表达有关。 |
| 关 键 词： | 青春期 乳房肥大症 ER CyclinD1蛋白 |
Expression of ER,CyclinD1 in glandular tissue of pubertal mammary hypertrophy |
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| Authors: | REN Min WANG Ying TENG Li WANG Ben-zhong |
| Institution: | REN Min, WANG Ying, TENG Li, WANG Ben-zhong.( Department of Breast Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China) |
| Abstract: | Objective To investigate the expression of the ER,CyclinD1 in breast tissue of pubertal mammary hypertrophy and explore the possible etiology of pubertal mammary hypertrophy.Methods The expression of ER,CyclinD1 was detected by Western-blot in 15 cases of pubertal mammary hypertrophy,15 normal breast tissue and 10 cases of micromastia.Results There was significant difference of the expression of ER,CyclinD1 within breast tissue between pubertal mammary hypertrophy and micromastia(P＜0.01).There was significant difference of the expression of ER,CyclinD1 within breast tissue in pubertal mammary hypertrophy and in normal breast tissue(P＜0.01).There was no difference between the expression of ER,CyclinD1 within breast tissue in micromastia and in normal breast tissue(P＞0.05).Conclusions The expression of ER,CyclinD1 in pubertal mammary hypertrophy are significantly higher than in micromastia and normal breast tissue.The pubertal mammary hypertrophy may be related to the expression status of ER,CyclinD1 within breast tissue. |
| Keywords: | ER Puberty Mammary hypertrophy ER CyclinD1 |
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