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双指标信息显著相似序列聚类分析桂附地黄丸金匮肾气丸无水乙醇提取物红外指纹图谱
引用本文:邹华彬. 双指标信息显著相似序列聚类分析桂附地黄丸金匮肾气丸无水乙醇提取物红外指纹图谱[J]. 中国中药杂志, 2009, 34(17): 49-55
作者姓名:邹华彬
作者单位:山东大学 化学与化工学院, 山东 济南 250100
摘    要:
目的:本研究提出了一种适用于复方中成药鉴别及质量控制的理论方法——双指标信息显著相似序列聚类分析。方法:根据作者等建立的共有峰率和变异峰率双指标序列分析法,构建了双指标信息方程,将共有遗传信息和变异信息综合成单一信息量,综合刻画生物样品的性质。确定双指标信息显著相似序列并用于聚类分析。结果:将该法应用于组成极其相似的桂附地黄丸和金匮肾气丸无水乙醇提取物红外指纹图谱分析,可以精细准确地将2种复方中成药分类。结论:本研究建立的双指标信息显著相似序列聚类分析法,是一种优良的适用于生物复杂体系的模式识别方法。

关 键 词:双指标信息;聚类分析;模式识别;桂附地黄丸;金匮肾气丸;指纹图谱
收稿时间:2009-05-06

Dual index information markedly similar sequence clustering analysis on IRfingerprint spectra of extracts of Guiful Dihuang and Jinkui Shenqi pills with ethanol
ZOU Huabin. Dual index information markedly similar sequence clustering analysis on IRfingerprint spectra of extracts of Guiful Dihuang and Jinkui Shenqi pills with ethanol[J]. China Journal of Chinese Materia Medica, 2009, 34(17): 49-55
Authors:ZOU Huabin
Abstract:
Objective: In this paper, a novel method-Dual index information markedly similar sequence clustering analysis suitable for identification and quality control of formula Chinese patent medicine was established. Method: Based on common and variation peak ratio dual index sequence analysis proposed by authors, a new equation was built up, in which the common inherited and variant information can be integrated into unique information represent. It describes the properties of biological samples simply and synthetically. The Dual index information markedly similar sequence were determined and used to clustersamples. Result: the novel approach was applied for pattern recognition of IR fingerprint spectra of components of Guiful dihuang and Jinkui shenqi pills, composed of extremely similar components extracted with ethanol, can be classified accurately and distinctly. Conclusion: the Dual index information markedly similar sequence clustering method is an excellent pattern recognition one fit to analyze biologically complex samples.
Keywords:Dual index information   clustering   pattern recognition   Guiful Dihuang Pill   Jinkui Shenqi pill   fingerprint spectra
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