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| 肝脏脂肪酸结合蛋白抗氧化作用研究进展 | |
| 引用本文： | 欧阳冬生,王珍珊,袁浩泳,严谨. 肝脏脂肪酸结合蛋白抗氧化作用研究进展[J]. 中国现代医学杂志, 2011, 21(26) |
| 作者姓名： | 欧阳冬生 王珍珊 袁浩泳 严谨 |
| 作者单位： | 1. 中南大学临床药理研究所,湖南长沙,410078 2. 中南大学基础医学院,湖南长沙,410083 3. 中南大学湘雅三医院,湖南长沙,410013 |
| 基金项目： | 湖南省科技计划项目(No:2007FJ3035); 国家大学生创新性实验计划项目(No:YB08105) |
| 摘 要： | 肝脏脂肪酸结合蛋白属于脂肪酸结合蛋白家族,蛋白结构中包含7个甲硫氨酸和一个半胱氨酸,对多不饱和脂肪酸和脂质过氧化代谢产物有很高的亲和力,参与调节脂肪酸在细胞内氧化和高活性代谢产物的清除,是机体内有效的抗氧化剂.肝脏脂肪酸结合蛋白作为内源性抗氧化剂在缺氧性疾病中发挥了重要作用. |
| 关 键 词： | 肝脏脂肪酸结合蛋白 抗氧化剂 活性氧簇 |
Advances in research on antioxidation effect of liver fatty acid binding protein |
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| OU-YANG Dong-sheng , WANG Zhen-shan , YUAN Hao-yong , YAN Jin. Advances in research on antioxidation effect of liver fatty acid binding protein[J]. China Journal of Modern Medicine, 2011, 21(26) | |
| Authors: | OU-YANG Dong-sheng WANG Zhen-shan YUAN Hao-yong YAN Jin |
| Affiliation: | OU-YANG Dong-sheng1,WANG Zhen-shan1,YUAN Hao-yong2,YAN Jin3(1.Clinical Pharmacology Institute,Central South University,Changsha,Hunan 410078,P.R.China,2.Basic Medical Science School,Hunan 410083,3.the Third Xiangya Hospital,Hunan 410013,P.R.China) |
| Abstract: | Liver fatty acid binding protein(L-FABP) is an important member of fatty acid binding protein family.L-FABP contains one cysteine and several methionine groups which take part in modulating fatty acids intracellular oxidation and inactivating ROS.L-FABP is effective antioxidant in vivo.It plays an important role in hypoxia diseases as endogenous antioxidants. |
| Keywords: | liver fatty acid binding protein antioxidant reactive oxygen species |
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