| 上皮-间质转化研究进展 |
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| 引用本文： | 张华东,黄勇,李宏伟,熊正文.上皮-间质转化研究进展[J].中国现代医学杂志,2011,21(31). |
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| 作者姓名： | 张华东 黄勇 李宏伟 熊正文 |
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| 作者单位： | 解放军第二五一医院病理科(北京军区肿瘤病理技术研究诊疗中心); |
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| 摘 要： | 上皮-间质转化的发生是一个多基因、多步骤、多阶段的复杂过程,是指上皮细胞在形态学上发生向成纤维细胞或间质细胞表型的转变并获得迁移的能力。上皮-间质转化是胚胎发育中的一个基本过程,它使在特殊部位产生的上皮细胞从上皮组织分离并迁移到其他位置,是正常发育、伤口愈合以及恶性上皮肿瘤发生的基础。该文主要介绍生长因子、转录因子、及其他调控因子在肿瘤上皮-间质转化中的调控功能,进一步综述上皮-间质转化在肿瘤侵袭转移中的作用。
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| 关 键 词： | 上皮间质转化 胚胎发育 肿瘤发生 肿瘤浸润转移 |
Research progress of epithelial-mesenchymal transition |
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| ZHANG Hua-dong,HUANG Yong,LI Hong-wei,XIONG Zheng-wen.Research progress of epithelial-mesenchymal transition[J].China Journal of Modern Medicine,2011,21(31). |
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| Authors: | ZHANG Hua-dong HUANG Yong LI Hong-wei XIONG Zheng-wen [ |
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| Institution: | ZHANG Hua-dong,HUANG Yong,LI Hong-wei,XIONG Zheng-wen [Department of pathology,the 251th Hospital of PLA(Beijing Military Treatment Technology Research Center Of Tumours),Hebei,Zhangjiakou 075000,P.R.China] |
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| Abstract: | The happening of epithelial-mesenchymal transition(EMT) is a complex process with multi-genes,multi-steps and multi-stages,where cells undergo a developmental switch from epithelial phenotype to mesenchymal phenotype and gain more ability of migration.EMT is a fundamental process governing morphogenesis in multicellular organisms.This process is also reactivated in a variety of diseases including fibrosis and carcinoma.This review mainly involves many molecular regulatory functions of growth factors,transcr... |
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| Keywords: | epithelial-mesenchymal transition embryonic development tumor tumor invasion and metastasis |
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