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| 糖尿病视网膜病变患者血清内脂素水平的变化及其与氧化应激的关系 | |
| 引用本文： | 张剑,李焕美,柴国禄. 糖尿病视网膜病变患者血清内脂素水平的变化及其与氧化应激的关系[J]. 中国现代医学杂志, 2011, 21(16) |
| 作者姓名： | 张剑 李焕美 柴国禄 |
| 作者单位： | 佳木斯大学附属第一医院眼科,黑龙江佳木斯,154003 |
| 摘 要： | 目的 观察糖尿病视网膜病变(DR)患者血清内脂素(visfatin)水平的变化及其与氧化应激的关系.方法 测定30例无DR的2型糖尿病患者(NDR组)、34例合并背景期DR的2型糖尿病患者(BDR组)、32例合并增殖期DR的2型糖尿病患者(PDR组)和30例正常对照组(NC组)的血清visfatin、丙二醛(MDA)和超氧化物歧化酶(SOD)的水平.结果 BDR组的血清visfatin和MDA明显高于NDR组(均P＜0.01),PDR组的血清visfatin和MDA明显高于BDR组(均P＜0.01).BDR组的血清SOD明显低于NDR组(P＜0.01),PDR组的血清SOD明显低于BDR组(P＜0.01).DR患者的血清visfatin与MDA、胰岛素抵抗指数(HOMA-IR)和三酰甘油呈明显正相关(r=0.521,r=0.427,r=0.516,均P＜0.01),与SOD呈明显负相关(r=-0.573,P＜0.01)o结论DR患者的血清visfatin水平升高,存在氧化应激,visfatin与氧化应激相互作用和相互影响,共同参与DR发病的病理生理过程. |
| 关 键 词： | 糖尿病视网膜病变 内脂素 丙二醇 超氧化物歧化酶 |
Changes of serum visfatin and relationship to oxidative strees in patients with diabetic retinopathy |
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| ZHANG Jian , LI Huan-mei , CHAI Guo-lu. Changes of serum visfatin and relationship to oxidative strees in patients with diabetic retinopathy[J]. China Journal of Modern Medicine, 2011, 21(16) | |
| Authors: | ZHANG Jian LI Huan-mei CHAI Guo-lu |
| Affiliation: | ZHANG Jian,LI Huan-mei,CHAI Guo-lu(Department of Ophthalmology,First Affiliated Hospital of Jiamusi University,Jiamusi,Heilongjiang 154003,P.R.China) |
| Abstract: | [Objective] To investigate the changes of serum visfatin and relationship between serum ivsfatin and oxidative stress in patients with diabetic retinopathy(DR).[Methods] 30 type 2 diabetic patients without DR(NDR group),34 type 2 diabetic patients with background DR(BDR group),32 type 2 diabetic patients with proliferative DR(PDR group) and 30 normal subjects(NC group) were observed.Their serum levels of visfatin,malonaldehyde(MDA) and superoxide dismutase(SOD) were measured.[Results] The serum levels of vi... |
| Keywords: | diabetic retinopathy visfatin malonaldehyde superoxide dismutase |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |