鼠神经生长因子治疗外伤性视神经病变的临床观察

目的:探讨鼠神经生长因子(NGF)治疗外伤性视神经病变的疗效及安全性。方法:外伤性视神经病变患者106例(106眼),随机分为常规治疗组44例和NGF治疗组62例,均给予常规治疗,NGF治疗组还给予鼠NGF,其中疗程3周者36例(3周亚组),疗程6周者26例(6周亚组)。治疗后随访3个月,比较各组患者治疗后视力恢复情况,并观察NGF治疗的安全性。结果:常规治疗组和NGF治疗组的总有效率分别为68.2%和88.7%,后者总有效率高于前者(P0.05);NGF治疗组内3周亚组的总有效率83.3%,6周亚组总有效率96.2%,后者总有效率高于前者(P0.05);除个别患者注射部位出现局部疼痛、红肿硬结外,未见其他不良反应。结论:鼠NGF治疗外伤性视神经病变安全、有效,值得临床推广应用。

Efficacy of Mouse Nerve Growth Factor in Treating Traumatic Optic Neuropathy

Objective:To investigate the efficacy and security of the mouse nerve growth factor (NGF) in treating traumatic optic neuropathy. Methods: One hundred and six patients with traumatic optic neuropathy were randomly divided into normal treatment group (n=44) and NGF treatment group (n=66). Patients in normal treatment group were treated with conventional treatment way and those in NGF treatment group were treated with NGF plus conventional treatment way. Patients in NGF treatment group were divided into 3-week subgroup and 6-week subgroup according to the period of treatment. Three months after treatment,the vision changes of different group were inspected and the safety was evaluated. Results: The total effective rate was 68.2% in normal treatment group and 88.7% in NGF treatment group (P<0.05). The total effective rate was 83.3% in 3-week subgroup and 96.2% in 6-week subgroup (P<0.05). Apart from local injection pain and swelling scleroma in several patients,other side effects were not found. Conclusion: Mouse NGF was an effective and safe way to treat traumatic optic neuropathy,which was worth widely applying in clinical practice.