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| 表皮生长因子受体抑制剂在胰腺癌治疗中的作用 | |
| 引用本文： | 孙慧玲,熊光苏,吴叔明. 表皮生长因子受体抑制剂在胰腺癌治疗中的作用[J]. 国际消化病杂志, 2008, 28(6) |
| 作者姓名： | 孙慧玲 熊光苏 吴叔明 |
| 作者单位： | 上海市消化疾病研究所,上海交通大学医学院附属仁济医院,200001;上海市消化疾病研究所,上海交通大学医学院附属仁济医院,200001;上海市消化疾病研究所,上海交通大学医学院附属仁济医院,200001 |
| 摘 要： | 胰腺癌是常见的消化道恶性肿瘤,传统的化疗和放疗效果均不甚理想。表皮生长因子受体(EGFR)信号转导通路在胰腺癌细胞的增殖、转移、血管形成等方面有重要作用,因此,针对EGFR信号通路的新型药物已陆续开发和应用。此文综述了EGFR的结构、功能以及EGFR抑制剂在胰腺癌治疗中的作用。 |
| 关 键 词： | 表皮生长因子受体 胰腺癌 EGFR抑制剂 |
The role of the epidermal growth factor receptor inhibitors in the treatment of pancreatic carcinoma |
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| SUN Hui-ling,XIONG Guang-su,WU Shu-ming. The role of the epidermal growth factor receptor inhibitors in the treatment of pancreatic carcinoma[J]. International Journal of Digestive Disease, 2008, 28(6) | |
| Authors: | SUN Hui-ling XIONG Guang-su WU Shu-ming |
| Abstract: | Pancreatic carcinoma is an unusually gastroenterology tumor and to date treatment with standard chemotherapy has yielded disappointing results.The epidermal growth factor receptor(EGFR)is over-expressed and plays an important role in proliferation,migration,neo-vascularization.Novel antineoplastics are developed by preferentially targeting inhibition of EGFR.The structures and functions of EGFR as well as current status of EGFR inhibitors are reviewed. |
| Keywords: | EGFR Pancreatic cancer EGFR inhibitors |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |