Antibody Specificity for HL-A in Human Myeloma Sera and Immune Rabbit Sera |
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| Authors: | G. Smith R. L. Walford B. Fishkin |
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| Affiliation: | Department of Patholology, School of Medicine, University of California, Los Angeles;and Department of Pathology, Wadsworth Veterans Hospital, Los Angeles, California, U.S.A. |
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| Abstract: | ![]()
Antibodies specific for HL-A antigens were found in sera of two out of four patients with multiple myeloma or gammopathy in the absence of known histoincompatible stimulation. By column chromatography fractionation of the sera the antibody activity was found in the abnormal immunoglobulin peak, and technical difficulties of cytotoxic testing of gammopathy sera were eliminated. Rabbit immune anti-human sera were shown to exhibit cytotoxic reaction patterns similar to one of the myeloma sera with a normal cell donor panel, which suggests the presence of an HL-A core substance or closely associated antigenic material. |
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