| 薯蓣皂苷对缺氧/复氧心肌细胞损伤的抗氧化作用研究 |
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| 引用本文： | 倪岚,许澎,伍旭升,陈飞.薯蓣皂苷对缺氧/复氧心肌细胞损伤的抗氧化作用研究[J].上海中医药杂志,2007,41(11):76-77. |
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| 作者姓名： | 倪岚 许澎 伍旭升 陈飞 |
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| 作者单位： | 复旦大学附属上海市第五人民医院心内科,上海,200240 |
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| 摘 要： | 目的评价薯蓣皂苷对心肌细胞的抗氧化保护作用。方法对培养的乳鼠心肌细胞造成缺氧/复氧损伤模型,比较正常对照组、缺氧/复氧损伤组、以及薯蓣皂苷各组(10ml/L、30ml/L、100ml/L)培养液中超氧化物歧化酶(SOD)、丙二醛(MDA)和一氧化氮(NO)含量。结果缺氧/复氧损伤组SOD活性明显降低,MDA和NO含量较正常显著升高;而薯蓣皂苷中、高剂量组上述指标都有不同程度的改善。结论薯蓣皂苷对缺氧/复氧造成的心肌细胞损伤具有保护作用,并呈现剂量依赖关系,作用机制与增强细胞抗氧化作用、减轻自由基和脂质过氧化物导致的细胞膜损伤有关。
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| 关 键 词： | 薯蓣皂苷 心肌细胞 抗氧化作用 |
| 文章编号： | 1007-1334（2007）11-0076-02 |
| 修稿时间： | 2007-04-16 |
Antioxidative Effect of Dioscin on Cardiomyocyte Following Hypoxia/Reoxygenation Injury |
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| NI Lan,XU Peng,WU Xu-sheng,CHEN Fei.Antioxidative Effect of Dioscin on Cardiomyocyte Following Hypoxia/Reoxygenation Injury[J].Shanghai Journal of Traditional Chinese Medicine,2007,41(11):76-77. |
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| Authors: | NI Lan XU Peng WU Xu-sheng CHEN Fei |
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| Abstract: | Objective To explore the antioxidative effects of Dioscin on cardiomyocyte. Methods To build the hypoxia/reoxygen(H/R) injury cardiomyocyte model, compare the control group, H/R group and Dioscin groups with different dosages, we analyzed the superoxide dismutase (SOD), malonaldehyde (MDA)and nitric oxide(NO). Results the SOD of H/R group decreased remarkablely, MDA and NO increased greatly, Dioscin increased SOD activity, inhibited MDA production, decreased the lever of NO. Conclusion Dioscin has a protective effect on H/R injury in cardiomyocyte and in a dose-dependent manner. |
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| Keywords: | Dioscin cardiomyocyte hypoxia/reoxygenation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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