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Interstitial cells of Cajal, the Maestro in health and disease
Authors:Randa M Mostafa Yasser M Moustafa Hosam Hamdy
Affiliation:Randa M Mostafa, Department of Basic Medical Sciences, College of Medicine, Sharjah University, Sharjah 27272, United Arab EmiratesYasser M Moustafa, Department of Pharmacology and Toxicology, College of Pharmacy, Suez Canal University, Ismaelia 24421, EgyptHosam Hamdy, Department of Surgery, Vice Chancellor of Medical and Health sciences Colleges, Sharjah University, Sharjah 27272, United Arab Emirates
Abstract:Interstitial cells of Cajal (ICC) are important players in the symphony of gut motility. They have a very signif icant physiological role orchestrating the normal peristaltic activity of the digestive system. They are the pacemaker cells in gastrointestinal (GI) muscles. Absence, reduction in number or altered integrity of the ICC network may have a dramatic effect on GI system motility. More understanding of ICC physiology will foster advances in physiology of gut motility which will help in a future break...
Keywords:Interstitial cells of Cajal   Gastrointestinal motility   Peristalsis  
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