单纯性肥胖男性儿童血清瘦素与胰岛素、雌二醇、睾酮的分析

目的：探讨单纯性肥胖男性儿童血清瘦素（leptin）与胰岛素（Ins）及性激素雌二醇（E2）、睾酮（T）的水平及其对性发育的影响。方法：测定各年龄组120例肥胖及120例正常的男性儿童血清的leptin及Ins,E2,T水平,进行比较并行相关性分析。结果：学龄前肥胖儿童与正常儿童比较,leptin,Ins有显著增高（P〈0.01）,而两组E2,T水平差异无显著性（P〉0.05）;青春早期、青春期肥胖儿童与正常儿童比较,leptin,Ins,E2有显著增高（P〈0.01）,而T降低（P〈0.05）。肥胖儿童血清leptin与Ins呈正相关（r=0.547,P〈0.01）,而leptin与T呈负相关（r=0.351,P〈0.05）;正常儿童leptin与各指标无明显相关（P〉0.05）。结论：单纯性肥胖儿童血清leptin和Ins同时升高,存在leptin抵抗、Ins抵抗;青春期肥胖男童leptin,E2升高,而T降低,存在性激素代谢紊乱,leptin可能影响男性肥胖儿童的性激素水平。

Analysis of serum leptin,insulin,estradiol and testosterone in male children with simple obesity

Objective：To explore the levels of serum leptin,insulin and sex hormone estradiol,testosterone in male children with simple obesity and their influence on the sexual development in children.Methods：Obesity group and control group were made up of 120 cases in each group.The levels of serum leptin,insulin,estradiol and testosterone were measured and statistical analysis of all the data were performed.Results：In preschool,the serum leptin and insulin levels in obese boys were obviously higher than those in normal boys （P〈0.01）, but there was no significant difference about the serum estradiol and testosterone levels between the two groups （P〉0.05）. In early puberty and puberty, compared with normal boys, the serum levels of leptin, insulin and estradiol in obese boys were significantly increased （P〈0.01）, but the levels of testosterone were reduced （P〈0.05）. There was a positive correlation between the levels of leptin and insulin in obese boys （r=0.547, P〈0.01）, but there was a negative correlation between the levels of leptin and testosterone（r=-0.351, P〈0.05）. There was no obvious correlation between the levels of leptin and other index in normal boys （P〉0.05）. Conclusion： The levels of serum leptin and insulin are obviously increased in obese children, indicating leptin resistance and insulin resistance.There is disturbance of sex hormones in adolescent obese boys. Leptin may affect the levels of sex hormone in obese boys.