多奈哌齐联合言语训练治疗脑卒中后失语症的临床观察

目的：观察多奈哌齐联合言语训练治疗脑卒中后失语症（PSA）的临床疗效.方法：PSA患者60例,随机分入2组各30例,2组均给予语言障碍ZM2.1行进言语康复训练,观察组加用多奈哌齐治疗.采用中国康复研究中心标准汉语失语症检查量表对失语症康复疗效进行评价.结果：治疗4周后,观察组除漫画说明外,余各项评分均较治疗前明显提高,对照组除句子朗读外,余各项评分均较治疗前明显提高（均P＜0.05）；观察组名词命名能力的改善优于对照组（P＜0.05）.结论：语言障碍ZM2.1语言康复训练对PSA患者的语言功能改善有效,多奈哌齐与其联合应用对改善PSA患者命名能力可能疗效更佳.

Clinical efficacy of donepezil combined with language training for post-stroke aphasia

Objective：To evaluate the efficacy of donepezil combined with language training for post-stroke aphasia （PSA）.Methods：Sixty patients with PSA were divided into observation group and control group randomly.Both groups were treated by language disorder ZM2.1.The observation group received treatment of donepezil hydrochloride additionally.All patients were assessed by Chinese Rehabilitation Research Center Standard Aphasia Examination （CRRCAE） before and at the endpoint of treatment respectively.Results：The scores of CRRCAE in observation group were higher than pretreatment except cartoon show,and the scores of CRRCAE in control group were higher than pretreatment,except sentences reading（all P＜0.05）.And the noun-naming ability in observation group was improved more significantly than in control group （P＜0.05）.Conclusion：Language function of PSA could be improved by rehabilitation treatment of language disorder ZM2.1,and donepezil combined with language disorder ZM2.1 may have more efficacy in noun-naming ability.