MicroRNA let-7a suppresses breast cancer cell migration and invasion through downregulation of C-C chemokine receptor type 7期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

MicroRNA let-7a suppresses breast cancer cell migration and invasion through downregulation of C-C chemokine receptor type 7

Authors:	Seok-Jun Kim Ji-Young Shin Kang-Duck Lee Young-Ki Bae Ki Woong Sung Seok Jin Nam Kyung-Hee Chun

Affiliation:	(1) Gastric Cancer Branch, Division of Translational & Clinical Research I, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 410-769, Republic of Korea;(2) Cancer Experimental Recourses Branch, Division of Cancer Biology, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 410-769, Republic of Korea;(3) Department of Surgery, School of Medicine, Sungkyunkwan University, Samsung Medical Center, 50 Irwon-dong, Gangnam-gu, Seoul, 135-710, Republic of Korea;(4) Department of Pediatrics, School of Medicine, Sungkyunkwan University, Samsung Medical Center, 50 Irwon-dong, Gangnam-gu, Seoul, 135-710, Republic of Korea;(5) Department of Biochemistry and Molecular Biology, Brain Korea 21 Project for Medical Science of Yonsei University, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea

Abstract:	Introduction C-C chemokine receptor type 7 (CCR7) plays an important role in chemotactic and metastatic responses in various cancers, including breast cancer. In the present study, the authors demonstrated that microRNA (miRNA) let-7a downregulates CCR7 expression and directly influences the migration and invasion of breast cancer cells.

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