ANALGESIC EFFECT OF APROTININ IN THE RAT AND ITS INHIBITION BY NALOXONE期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

ANALGESIC EFFECT OF APROTININ IN THE RAT AND ITS INHIBITION BY NALOXONE

Authors:	NOVELLI, G. P. PIERACCIOLI, E. PEDUTO, V. A. FESTIMANNI, F.

Affiliation:	Institute of Anaesthesiology and Intensive Care, University of Florence 50134 Florence, Italy

Abstract:	Experiments were performed on rats using two analgesimetrictests (tail-flick; hot-plate) before and after injection i.v.of graded doses of apruunin (12.5, 25.0 and 50 KIU g¹).A dose-related analgesic effect was noted with both tests. Prioradministration of naloxone 0.001 mg g¹ i.p. inhibitedthe analgesic action.

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