乳腺-甲状腺多原发癌的临床分析

目的探讨乳腺-甲状腺多原发癌的临床特点。方法收集2010-05—2016-05间在郑州大学第二附属医院诊断为乳腺-甲状腺多原发癌患者24例,对其临床资料进行回顾性分析。结果 (1)24例乳腺-甲状腺多原发癌均为女性。(2)同时癌9例,异时癌15例。乳腺癌首发12例,甲状腺癌首发3例。(3)两原发癌发生间隔时间在3a内的18例,占75%。(4)乳腺多原发癌与乳腺单癌发病诊断年龄无统计学差异,甲状腺多原发癌发病诊断年龄与甲状腺单癌发病诊断年龄比较,差异无统计学意义(P0.05)。(5)多原发癌中乳腺首发癌浸润性癌占80.95%;再发癌以导管内癌为主,占66.66%。多原发癌中甲状腺癌均为乳头状癌,其首发癌与再发癌中乳头状微小癌分别为83.33%、91.66%。(6)乳腺多原发癌ER阳性率为62.5%,乳腺单发癌ER阳性率52.63%,差异无统计学意义(P0.05)。(7)24例多原发癌中,乳腺癌与甲状腺癌,均获得根治性手术机会,预后良好。结论乳腺-甲状腺多原发癌的第二原发癌好发于3a内,其再发癌肿瘤分化好,临床分期较早。早发现、早诊断,治疗效果好。

Clinical Characteristics of breast and thyroid multiple primary carcinomas

Objective To investigate the clinical features of multiple primary breast and thyroid cancers.Methods The clinical features of 24 patients with pathologically confirmed multiple primary breast and thyroid cancers who were treated in our hospital between May 2010 and May 2016 were retrospectively analyzed.Results (1) All patients were women;(2) 8 cases were synchronous breast and thyroid cancers;25 cases were metachronous breast and thyroid cancers.For 12 patients with thyroid carcinoma after breast carcinoma, For 3 patients with breast carcinoma after thyroid carcinoma.(3)Two primary carcinomas occurrence time interval within three years in 18 cases, accounting for 75%;(4)there is no difference between breast and thyroid multiple primary carcinomas with single breast carcinoma and thyroid carcinoma(P>0.05);(5) the invasive ductal carcinoma were 80.95% in the first primary carcinoma of breast and the intraductal carcinoma were 66.66% in the second primary carcinoma of breast;the thyroid carcinoma of multiple primary carcinomas all were papillary carcinoma ,there were papillary thyroid micro carcinoma 83.33%、91.66% in the first primary carcinoma and the second primary carcinoma of the thyroid multiple primary carcinomas;(6) 62.5% were ER (+) in the breast multiple primary carcinomas and 52.63% were ER (+) in single breast carcinomas, there is no difference between both(P>0.05);(7) all of 24 cases breast and thyroid multiple primary carcinomas have a chance for operative of radical prostatectomy.Conclusion The second carcinomas of breast and thyroid multiple primary carcinomas often happen in 3 years;recurrence of carcinomas have well differentiated and the clinical stage.early detection, early diagnosis and treatment effect is good.