Comparison of cross-sectional renal function measurements in African Americans with hypertensive nephrosclerosis and of primary formulas to estimate glomerular filtration rate |
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| Affiliation: | 1. Paediatric Infectious Diseases Research Group, St George''s University of London, London, UK;2. Evelina Children''s Hospital, London, UK;3. Norfolk and Norwich University Hospital, Norwich, UK;4. John Radcliffe Hospital, Oxford, UK;5. Croydon University Hospital, London, UK;6. Royal Cornwall Hospitals NHS Trust, Truro, UK;7. Royal Victoria Infirmary, Newcastle, UK;8. St George''s Hospital NHS Trust, London, UK;9. Bolton NHS Foundation Trust, Bolton, UK;1. Robert Koch Institute, HIV and Other Retroviruses, Nordufer 20, 13353 Berlin, Germany;2. Medizinische Klinik und Poliklinik IV, Diabeteszentrum, Ludwig-Maximilians-Universität, München, Ziemssenstraße 1, 80336 München, Germany;3. German Primate Center, Leibniz-Institute, Pathology Unit, Kellnerweg 4, 37077 Göttingen, Germany;4. Chair for Molecular Animal Breeding and Biotechnology and Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, Ludwig-Maximilians-Universität München, Hackerstraße 27, 85764 Oberschleißheim, Germany;1. Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599;2. DILIsym Services Inc., Research Triangle Park, North Carolina 27709;3. Department of Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co., Cambridge, Massachusetts 02139;4. Qualyst Transporter Solutions, Durham, North Carolina 27713;1. Department of Surgical Gastroenterology, King George''s Medical University, Lucknow, Uttar Pradesh, India;2. Developmental Toxicology Division, Indian Institute of Toxicology Research (IITR), Lucknow, Uttar Pradesh, India;3. Department of Surgery, King George''s Medical University, Lucknow, Uttar Pradesh, India;1. Department of Medicine, The Johns Hopkins University, Baltimore, MD, USA;2. Department of Surgery, The Johns Hopkins University, Baltimore, MD, USA |
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| Abstract: | ![]()
Renal function measurements were obtained in 1,703 African Americans with presumed hypertensive nephrosclerosis who were screened for entry into the African-American Study of Hypertension and Kidney Disease (AASK). We examined the effect of race on relationships involving renal variables by comparing African Americans enrolled into the AASK with non-African Americans enrolled into the Modification of Diet in Renal Disease (MDRD) study. We examined the effect of gender on renal variables by comparing African American men and women. We compared various methods for estimating glomerular filtration rate (GFR) with iodine 125-labeled (125I)-iothalamate GFR. AASK data were also used to derive a new formula for estimating GFR in African Americans. After adjusting for age, sex, and baseline GFR, African American patients on the AASK study were heavier and had larger body surface areas and body mass indices than either MDRD African Americans or non-African Americans. African Americans had greater serum creatinine levels and urinary creatinine excretions for any given level of GFR. Mean GFR was greater in African American men than African American women (59.7 versus 51.7 mL/min/1.73 m2), although serum creatinine levels were also greater in men (1.91 versus 1.73 mg/dL). Seventy-eight percent of women with serum creatinine levels between 1.2 and 1.5 mg/dL had GFRs less than 65 mL/min/1.73 m2. For African Americans in the AASK, GFR was overestimated by the 24-hour creatinine clearance and underestimated by the Cockcroft-Gault formula. A prediction formula developed in the MDRD study more accurately predicted GFR in AASK patients than these measurements. AASK data were also used to derive a new five-term formula for estimating GFR that was slightly more accurate in the African Americans in the AASK than the MDRD formula (median percentage of error, 12.4% for the MDRD formula versus 12.1% for the AASK formula). Important differences exist in renal variables between African Americans and non-African Americans and between African American men and African American women. Formulas using demographic data and readily measured serum values estimate 125I-iothalamate GFR. © 2001 by the National Kidney Foundation, Inc. |
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| Keywords: | Glomerular filtration rate (GFR) African Americans African-American Study of Hypertension and Kidney Disease (AASK) |
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