富血小板血浆促进骨修复的机制及应用

背景:目前普遍认为富血小板血浆具有促进骨修复的作用,但其具体机制尚未完全阐明,富血小板的最佳应用方式仍不明确。目的:综述近期富血小板血浆促进骨修复机制及应用的研究进展。方法:由第一作者检索1995/2011PubMed与CNKI数据库有关富血小板血浆促进骨修复机制及应用的相关文献,排除与研究目的相关性差及内容陈旧、重复的文献。中文关键词为"富血小板血浆,生长因子,骨修复",英文关键词为"Platelet-rich plasma,Growth factor,Bone repair"。共纳入25篇符合标准的文献进行综述。结果与结论:富血小板血浆含有多种高浓度生长因子,普遍的观点认为聚合过程中血小板脱颗粒释放多种生长因子联合作用加速了骨修复的过程。单独应用富血小板血浆对骨修复的治疗效果不如与其他物质复合使用效果明显。

Application of platelet-rich plasma for bone repair and its mechanism

BACKGROUND:Presently,it is widely accepted that platelet-rich plasma can accelerate bone repair.However,the mechanism of platelet-rich plasma in promoting bone repair has not been clarified;the best method to apply the platelet-rich plasma is still not definite.OBJECTIVE:To review the application and mechanism of platelet-rich plasma on bone repair in recent years.METHODS:A computer-based retrieval was performed by the first author in PubMed database and CNKI database to search papers about the application of platelet-rich plasma on bone repair and the mechanism of action.The Key words were "platelet-rich plasma,growth factor,bone repair" in Chinese and English,respectively.The papers that did not meet the purposes of the author or obsolete and repeated were excluded.A total of 25 papers were included according to the inclusion criteria. RESULTS AND CONCLUSION:Platelet-rich plasma is highly concentrated plasma enriched with platelets and various growth factors.Generally,the combination of many high-concentration growth factors released from blood platelet degranulation during polymerization could stimulate bone formation and accelerate bone repair.The effect of single platelet-rich plasma for bone repair is inferior to that of platelet-rich plasma compound with other substances.