聚氨基酸/羟基磷灰石椎间融合器植入山羊颈椎

背景:聚氨基酸/纳米羟基磷灰石复合材料已被研究证实具有良好的生物安全性。目的:观察聚氨基酸/羟基磷灰石椎间融合器对山羊颈椎的融合效果。方法:取成年雄性山羊,切除C3、4椎间盘,清除软骨终板,随机分成实验组与对照组,分别植入聚氨基酸/羟基磷灰石颈椎间融合器与自体髂骨。术后2,4,8,12周行X射线检查;术后4,12周行CT扫描和组织学检查。结果与结论:术后2周,实验组平均椎间高度高于对照组(P<0.05),术后4~12周,两组平均椎间高度差异无显著性意义。术后4周,实验组融合度评分差于对照组(P<0.05),术后12周两组融合度评分差异无显著性意义。术后4,12周,两组均可观察到从成骨细胞集聚、胶原增生到新骨形成的过程。表明聚氨基酸/羟基磷灰石椎间融合器具有良好的初始稳定性和融合效果,是一种理想的椎间融合装置。

Intervertebral fusion cage made by poly-amino acid/hydroxyapatite composites in a goat cervical spine model

BACKGROUND:Poly-amino acid/nano-hydroxyapatite composite material has been proved to have a good bio-security. OBJECTIVE:To evaluate the fusion effect of poly-amino acid/nano-hydroxyapatite interbody cage in a goat cervical spine model. METHODS:Sixteen adult male goats underwent C3-4 discectomy and intervertebral fusion with poly-amino acid/nano-hydroxyapatite interbody cage (experimental group, n=8) or autogenous iliac (control group, n=8). X-ray was taken at 2, 4, 8 and 12 weeks after surgery to measure the intervertebral height. CT scanning and histology examination were performed at 4 and 12 weeks after surgery. RESULTS AND CONCLUSION:Referring to radiography and histomorphology findings, the goats with poly-amino acid/nano-hydroxyapatite cage or autograft all showed fine fusion at 12 weeks, without significant difference. The intervertebral fusion cage of poly-amino acid/nano-hydroxyapatite has good initial stability and fusion which may be an ideal interbody fusion appliance.