腰椎间盘退变中的细胞因子及炎症递质:文献分析与临床应用

背景:通过分析细胞因子及炎症递质对腰椎间盘退变的影响,有助于深入认识腰椎间盘退变的发病机制,指导临床对腰椎间盘退变疾病的预防和治疗。目的:结合临床对腰椎间盘退变中细胞因子及炎症递质进行研究,并对其发展趋势进行多层次探讨分析。方法:以电子检索方式对CNKI数据库学术期刊2002-01/2011-12收录有关腰椎间盘退变中细胞因子及炎症递质研究的文献进行分析,采用检索词主要为"腰椎间盘退变;细胞因子;炎症介质",运用数据库的分析功能和Excel软件图表的功能分析数据特征。结合2009-01/12在解放军第306医院骨科进行腰椎间盘突出症治疗的患者67例,治疗方法为单节段椎管减压,椎间融合器植入植骨融合内固定,对术中切除的间盘进行镜下和免疫组织化学分析。结果与结论:在CNKI数据库学术期刊2002/2011收录的文献中,共检索到76篇与腰椎间盘退变细胞因子及炎症递质研究相关的文献,文献数量处于上升趋势。腰椎间盘退变中细胞因子及炎症递质研究检测方法以免疫组织化学为主,对炎症递质的表达定量定性准确性研究较多。可见,细胞因子及炎症递质在椎间盘退变的复杂病理过程中具有重要的调控作用。

Effect of cytokines and inflammatory mediators on lumbar intervertebral disc degeneration

BACKGROUND:Analyzing the effect of cytokines and inflammatory mediators in the lumbar intervertebral disc degeneration may contribute to a better understanding of the pathogenesis of lumbar intervertebral disc degeneration,and guide the clinical orthopedic surgeons for the prevention and treatment of degenerative disc disease.OBJECTIVE:To multi-level explore and analyze the effect of cytokines and inflammatory mediators on lumbar intervertebral disc degeneration.METHODS:A computer-based search was performed in CNKI database from January 2002 to December 2011 for the literatures related to the effect of cytokines and inflammatory mediators in the lumbar intervertebral disc degeneration.The Key words were "lumbar intervertebral disc degeneration,cytokines,inflammatory mediators" in Chinese,and the analysis capabilities of the database and Excel chart function were used to analyze the data characteristics. RESULTS AND CONCLUSION:A total of 76 articles related to the effect of cytokines and inflammatory mediators in the lumbar intervertebral disc degeneration were screened out from CNKI database from 2002 to 2011.The number of the literature was on an increasing trend.The research about the effect of cytokines and inflammatory mediators on lumbar intervertebral disc degeneration mainly depended on immunohistochemistry,and most of the researches were about the quantitative,qualitative and accurate expression of inflammatory mediators.So the cytokines and inflammatory mediators play an important role in regulating the complex pathological process of lumbar intervertebral disc degeneration.