六味五灵片治疗抗结核药所致轻度肝损伤的临床分析

目的:观察六味五灵片治疗抗结核药物引起的轻度药物性肝损伤的临床疗效。方法:将65例抗结核药物引起的药物性肝损伤患者随机分为两组,治疗组(n=35)患者接受六味五灵片治疗,1.5g/次,3次/d;对照组(n=30)患者接受甘利欣胶囊治疗,100mg/次,3次/d;均在不调整抗结核药物治疗基础上治疗2周,观察治疗第1周、第2周后患者血清肝功能指标ALT、AST、TBil水平变化,比较两组的疗效。结果:治疗组和对照组患者血清ALT、AST水平在治疗第1周、第2周时与治疗前比较差异均有显著性意义(均P<0.001),两组间同期比较,差异有显著性意义(P<0.05);治疗两周时,治疗组与对照组患者血清TBil水平比较,差异有显著性意义(P<0.05);治疗组和对照组的总有效率分别是94.3%和76.6%,组间比较差异有显著性意义(P<0.05)。结论:六味五灵片治疗抗结核药物引起的轻度肝损伤起效快,疗效高,明显优于甘利欣胶囊。

Clinical analysis of Liuweiwuling therapy for patients with mild anti-tuberculosis drug-induced liver injury

Objective:To observe the clinical effect of tablet Liuweiwuling therapy for patients with mild anti-tuberculosis(TB) mild drug-induced liver injury(DILI).Methods:Anti-TB-DILI patients(65 cases) were randomly divided into treatment group(35 cases) and control group(30 cases).Treatment group patients received tablet Liuweiwuling,1.5g a time,3 times a day.Control group received capsule Ganlixin,100mg a time,3 times a day.Based on did not adjust anti-TB drugs,all patients were treated for 2 weeks.The serum level of ALT,AST and TBil in two groups were observed at the first and second week,the curative effect of the two groups were compared.Results:The level of ALT and AST in the treatment and control group patients′serum at post-therapy of 1 week and 2 weeks compared with pre-therapy,there were significant differences(all P<0.001),and compared the same time point post-therapy were significant differences between the two groups(P<0.05).The level of TBil in treatment group patients compared with control group at post-therapy of 2 weeks were significant differences(P<0.05).Total effective rate of the treatment and control group were 94.3% and 76.6%,respectively,and there were significant differences between two groups(P<0.05).Conclusion:Tablet Liuweiwuling therapy for patients with mild anti-TB-DILI shows faster and higher efficacy compared with capsule Ganlixin.